Normal view MARC view ISBD view

Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?

Bansi, L.K.

Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression? - 2008

NMUH Staff Publications 22

<div style="line-height: 17.999801635742188px;"><h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">OBJECTIVE:</h4>We investigated whether previous treatment interruptions are associated with a raised risk of viral rebound in individuals who have attained virological suppression.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">METHODS:</h4>All patients achieving an undetectable viral load while on therapy were followed until viral rebound or the time of the last viral load. Poisson regression was used to describe the independent impact of treatment interruptions on rebound rates.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">RESULTS:</h4>A total of 12,977 patients from the United Kingdom Collaborative HIV Cohort (UK CHIC) Study achieved a viral load of less than 50 copies/ml. These patients contributed a total of 37,314 person-years of follow-up. The overall rebound rate was 8.07 (7.78, 8.36) per 100 person-years. In adjusted analyses, rates of viral rebound were up to 64% higher (rate ratio 1.64; 1.43, 1.88) in those who had previously interrupted therapy compared with those who had not. Patients who had interrupted at detectable viral loads had up to a 74% (1.74; 1.42, 2.14) higher chance of rebounding compared with those who had not interrupted with a detectable viral load. We found no evidence to suggest interrupting treatment at an undetectable viral load was associated with viral rebound.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">CONCLUSION:</h4>Among patients with an undetectable viral load, having previously interrupted therapy while the viral load was detectable is associated with a raised risk of rebound.</div>

ISSN: 02699370

Print
Add to your folder (remove)
Save record
BIBTEX Dublin Core MARCXML MARC (non-Unicode/MARC-8) MARC (Unicode/UTF-8) MARC (Unicode/UTF-8, Standard) MODS (XML) RIS
More searches

Search for this title in:
Google Scholar Copac British Library NHS Knowledge and Library Hub

Storage	Name	Value	Expiration	Description
Cookie	CGISESSID	Session ID	Until logout or end of session	Session cookie
Cookie	KohaOpacLanguage	Language code	3 years	Stores the language the user selected, so the online catalog will appear in that same language the next time it is visited.
Cookie	form_serialized form_serialized_limits	Search terms and limits	End of session or when the advanced search page is accessed again.	jQuery cookie. Stores search terms and limits of the last advanced search. Set when an advanced search is submitted.
Cookie	search_path_code	ads (fewer) or exs (more)	End of session or when the advanced search page is accessed again.	jQuery cookie. Related to serialized_form* cookies. Stores if the advanced search form was used with 'More options' or 'Fewer options'.
Cookie	num_paragraph	Count of search options added	End of session or when the advanced search page is accessed again.	jQuery cookie. Used to store the number of created options when user selects 'More options' in advanced search to increase search boxes.
Cookie	bib_list	List of record IDs (biblionumbers) separated by /	End of session or until the cart is emptied.	Stores cart contents in the online catalog. Set when records are added to the cart for the first time.