Parkinson's disease : diagnosis, treatment, and prognosis
Parkinson's disease : diagnosis, treatment, and prognosis [E-Book]
- New York : Nova Science Publishers, Inc., [2012]
- 1 online resource (xii, 232 pages : illustrations).
- Neurodegenerative Diseases : Laboratory and Clinical Research .
- Neurodegenerative diseases--laboratory and clinical research. .
Includes bibliographical references and index.
""PARKINSON'S DISEASE ""; ""PARKINSON'S DISEASE ""; ""CONTENTS ""; ""PREFACE ""; ""THERAPEUTIC INTERVENTION AT CELLULAR CLEARANCE MECHANISMS: SIGNIFICANCE TO PARKINSON�a�?S DISEASE ""; ""ABSTRACT ""; ""ABBREVIATIONS ""; ""1. INTRODUCTORY REMARKS ""; ""2. INTRACELLULAR CLEARANCE MECHANISMS ""; ""2.1. The Ubiquitin Proteasome System ""; ""2.1.1. Quality Control through the Ubiquitin Proteasome System ""; ""2.1.2. Ubiquitin Proteasome System impairment in PD ""; ""2.2. The Autophagy-Lysosomal Pathway ""; ""2.2.1. Quality Control through the Autophagic- Lysosomal Pathway "" ""2.2.2. Autophagy- Lysosomal Pathway dysfunction in PD """"2.3. Enzymatic Proteolytic Systems ""; ""2.3.1. Quality Control through Cytosolic Proteolysis: Calpains ""; ""2.3.2. Quality Control through Mitochondrial Proteolysis: Lon, Clp-Like, AAA-Proteases ""; ""2.3.3. Enzymatic Proteolysis Disruption in PD ""; ""3. THERAPEUTIC INTERVENTIONS BASED ON THE MODULATION OF CLEARANCE MECHANISMS ""; ""3.1. Proteasomal Clearance �a�? A Target for Therapeutic Intervention ""; ""3.2. Autophagic Clearance �a�? A Target for Therapeutic Intervention "" ""3.3. Proteases Clearance �a�? A Target for Therapeutic Intervention """"CONCLUSION ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES""; ""PARKINSON�a�?S DISEASE RELATED CHANGES OF OSCILLATORY ACTIVITY IN DISCRIMINATION TASKS ""; ""ABSTRACT ""; ""1. INTRODUCTION ""; ""2. METHODS ""; ""2.1. Experimental Procedure""; ""2.2. Analysis ""; ""3. EXPERIMENTAL RESULTS ""; ""Early (0�a�?250 ms) Post-stimulus Interval ""; ""Late (250�a�?600 ms) Post-stimulus Interval ""; ""4. DISCUSSION ""; ""CONCLUSION ""; ""REFERENCES "" ""NEW INSIGHTS INTO THE MECHANISM OF SLOWING OF VOLUNTARY MOVEMENTS IN PARKINSON�a�?S DISEASE """"ABSTRACT ""; ""ABBREVIATIONS ""; ""1. INTRODUCTION""; ""2. ANATOMIC ORGANIZATION OF THE BASAL GANGLIA ""; ""2.1. General Organization ""; ""2.2. Input and Output of Striatum and SNpc Connections ""; ""2.3. Input and Output of GP and SNpr, and STN Connections ""; ""2.4. Summary ""; ""3. PHYSIOLOGICAL FINDINGS OF THE BASAL GANGLIA IN ANIMALS ""; ""3.1. Neuronal Activity in Striatum, GPe and GPi ""; ""3.2. Neuronal Activity in STN, SNpc and SNpr "" ""3.3. Sequential Motor Actions and the Basal Ganglia""""3.4. Summary ""; ""4. CLINICAL SYMPTOMS OF PARKINSON�a�?S DISEASE ""; ""4.1. Slowness of Movement and Abnormal Movement Sequence ""; ""4.2. Impaired Synergy of Movement/Posture and Freezing, Loss of Postural Reflex and Festination""; ""4.3. Prolongation of Reaction Time ""; ""4.4. Reorganized Voluntary Eye Hand Coordinated Movement""; ""4.5. Impaired Time Perception and Reproduction ""; ""4.6. Summary ""; ""5. FUNCTIONAL CONSIDERATIONS OF SPATIO-TEMPORAL PROCESSING FOR MOVEMENT SYNERGY IN THE BASAL GANGLIA AND PARKINSON�a�?S DISEASE ""
English.
1619428377 9781619428379
Parkinson's disease.
Symptomatic Parkinson's disease.
Brain--Diseases.
Brain Diseases
Parkinson Disease
Parkinson Disease, Secondary
Includes bibliographical references and index.
""PARKINSON'S DISEASE ""; ""PARKINSON'S DISEASE ""; ""CONTENTS ""; ""PREFACE ""; ""THERAPEUTIC INTERVENTION AT CELLULAR CLEARANCE MECHANISMS: SIGNIFICANCE TO PARKINSON�a�?S DISEASE ""; ""ABSTRACT ""; ""ABBREVIATIONS ""; ""1. INTRODUCTORY REMARKS ""; ""2. INTRACELLULAR CLEARANCE MECHANISMS ""; ""2.1. The Ubiquitin Proteasome System ""; ""2.1.1. Quality Control through the Ubiquitin Proteasome System ""; ""2.1.2. Ubiquitin Proteasome System impairment in PD ""; ""2.2. The Autophagy-Lysosomal Pathway ""; ""2.2.1. Quality Control through the Autophagic- Lysosomal Pathway "" ""2.2.2. Autophagy- Lysosomal Pathway dysfunction in PD """"2.3. Enzymatic Proteolytic Systems ""; ""2.3.1. Quality Control through Cytosolic Proteolysis: Calpains ""; ""2.3.2. Quality Control through Mitochondrial Proteolysis: Lon, Clp-Like, AAA-Proteases ""; ""2.3.3. Enzymatic Proteolysis Disruption in PD ""; ""3. THERAPEUTIC INTERVENTIONS BASED ON THE MODULATION OF CLEARANCE MECHANISMS ""; ""3.1. Proteasomal Clearance �a�? A Target for Therapeutic Intervention ""; ""3.2. Autophagic Clearance �a�? A Target for Therapeutic Intervention "" ""3.3. Proteases Clearance �a�? A Target for Therapeutic Intervention """"CONCLUSION ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES""; ""PARKINSON�a�?S DISEASE RELATED CHANGES OF OSCILLATORY ACTIVITY IN DISCRIMINATION TASKS ""; ""ABSTRACT ""; ""1. INTRODUCTION ""; ""2. METHODS ""; ""2.1. Experimental Procedure""; ""2.2. Analysis ""; ""3. EXPERIMENTAL RESULTS ""; ""Early (0�a�?250 ms) Post-stimulus Interval ""; ""Late (250�a�?600 ms) Post-stimulus Interval ""; ""4. DISCUSSION ""; ""CONCLUSION ""; ""REFERENCES "" ""NEW INSIGHTS INTO THE MECHANISM OF SLOWING OF VOLUNTARY MOVEMENTS IN PARKINSON�a�?S DISEASE """"ABSTRACT ""; ""ABBREVIATIONS ""; ""1. INTRODUCTION""; ""2. ANATOMIC ORGANIZATION OF THE BASAL GANGLIA ""; ""2.1. General Organization ""; ""2.2. Input and Output of Striatum and SNpc Connections ""; ""2.3. Input and Output of GP and SNpr, and STN Connections ""; ""2.4. Summary ""; ""3. PHYSIOLOGICAL FINDINGS OF THE BASAL GANGLIA IN ANIMALS ""; ""3.1. Neuronal Activity in Striatum, GPe and GPi ""; ""3.2. Neuronal Activity in STN, SNpc and SNpr "" ""3.3. Sequential Motor Actions and the Basal Ganglia""""3.4. Summary ""; ""4. CLINICAL SYMPTOMS OF PARKINSON�a�?S DISEASE ""; ""4.1. Slowness of Movement and Abnormal Movement Sequence ""; ""4.2. Impaired Synergy of Movement/Posture and Freezing, Loss of Postural Reflex and Festination""; ""4.3. Prolongation of Reaction Time ""; ""4.4. Reorganized Voluntary Eye Hand Coordinated Movement""; ""4.5. Impaired Time Perception and Reproduction ""; ""4.6. Summary ""; ""5. FUNCTIONAL CONSIDERATIONS OF SPATIO-TEMPORAL PROCESSING FOR MOVEMENT SYNERGY IN THE BASAL GANGLIA AND PARKINSON�a�?S DISEASE ""
English.
1619428377 9781619428379
Parkinson's disease.
Symptomatic Parkinson's disease.
Brain--Diseases.
Brain Diseases
Parkinson Disease
Parkinson Disease, Secondary
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