Role of oxidative stress, mitochondria failure, and cellular hypoperfusion in the context of Alzheimer disease : past, present and future
Aliev, Gjumrakch.
Role of oxidative stress, mitochondria failure, and cellular hypoperfusion in the context of Alzheimer disease : past, present and future [E-Book] - 1 online resource. - Neurology--laboratory and clinical research developments Aging issues, health and financial alternatives . - Neurology--laboratory and clinical research development series. Aging issues, health and financial alternatives series. .
Includes bibliographical references and index.
THE ROLE OF OXIDATIVE STRESS, MITOCHONDRIA FAILURE, AND CELLULAR HYPOPERFUSION IN THE CONTEXT OF ALZHEIMER DISEASE ; THE ROLE OF OXIDATIVE STRESS, MITOCHONDRIA FAILURE, AND CELLULAR HYPOPERFUSION IN THE CONTEXT OF ALZHEIMER DISEASE ; Dedication and Acknowledgments ; Contents ; Preface ; Are Mitochondrial Failures a Key Component in Alzheimer Disease? ; Abstract ; Acknowledgments ; References ; In Vivo and In Vitro Assessment of the Brain Mitochondrial Bioenergetics in Aging Rats ; Abstract ; Introduction ; Materials and Methods ; Animals ; Methods. In vivo 31P Magnetic Resonance Spectroscopy In Vitro Mitochondrial Respiration ; In Vitro Mitochondrial Oxidative Phosphorylation (Table 2 and Figure 2) ; Endogenous Antioxidants ; Statistical Methods ; Results ; In Vivo 31P Magnetic Resonance Spectroscopy ; Endogenous Antioxidants (Table 3 and Figure 3) ; Discussion ; Acknowledgments ; References ; The Pathophysiology of Cerebrovascular Lesions in Alzheimer Disease ; Abstract ; The Effect of Oxidative Stress on Brain Microvessel Function in AD ; Neuropathologic Features of Cerebrovascular Lesions. Hypoperfusion as a Factor in the Development of AD Relationships between Apolipoprotein E (ApoE) Genotype, Hypercholesterolemia, and Vascular Changes in AD ; Hypoxia/Ischemia/Reperfusion as Cofactors for Oxidative Stress Induced Cerebrovascular Lesions and their Relationship to AD ; The Role of Mitochondrial Abnormalities in the Patho-Genesis of Oxidative Stress-Induced Brain Lesions in AD ; The Role of Endothelial Vasoactive Substancesin the Pathophysiology of Brain Ischemia/Reperfusion and AD ; Transgenic Animals as Models for Studying Cerebrovascular Lesions in AD. Prevention of AD Using Selective Pharmacological Treatments Conclusion and Considerations for the Future; Acknowledgments ; References ; Vascular Pathology in the Pathogenesis of Alzheimer Disease ; I. Epidemiological Findings ; II. Elements of Brain Tissue Metabolism; III. Causes and Risk Factors ; Inflammatory System ; Vascular Pathology ; 1. Mitochondrial Dysfunction in AD ; 2. Hypoxia and AD ; 3. History of Stroke, Cerebral Ischemia and AD ; 4. Hypertension and Alzheimer Disease ; Acknowledgments ; References. Oxidative Stress Induced Mitochondrial Failure and Cellular Hypoperfusion as Primary Pathogenic Factors for the Development and Progression of Alzheimer Disease Abstract ; Introduction ; Cerebral Vascular Energy Requirements: Hypoperfusion as a Key Factor for the Development of AD ; The Effect of Oxidative Stress on Brain Microvessel Function and A Deposition in AD; Morphometric and Neuropathological Features of CerebroVascular Lesions and A in AD ; Relationships between ApoE Genotype, Hypercholesterolemia, A and Vascular Changes in AD.
9781619428973 1619428970
2020678324
016063297 Uk
Alzheimer's disease.
Oxidative stress.
Mitochondrial pathology.
Cell respiration.
Role of oxidative stress, mitochondria failure, and cellular hypoperfusion in the context of Alzheimer disease : past, present and future [E-Book] - 1 online resource. - Neurology--laboratory and clinical research developments Aging issues, health and financial alternatives . - Neurology--laboratory and clinical research development series. Aging issues, health and financial alternatives series. .
Includes bibliographical references and index.
THE ROLE OF OXIDATIVE STRESS, MITOCHONDRIA FAILURE, AND CELLULAR HYPOPERFUSION IN THE CONTEXT OF ALZHEIMER DISEASE ; THE ROLE OF OXIDATIVE STRESS, MITOCHONDRIA FAILURE, AND CELLULAR HYPOPERFUSION IN THE CONTEXT OF ALZHEIMER DISEASE ; Dedication and Acknowledgments ; Contents ; Preface ; Are Mitochondrial Failures a Key Component in Alzheimer Disease? ; Abstract ; Acknowledgments ; References ; In Vivo and In Vitro Assessment of the Brain Mitochondrial Bioenergetics in Aging Rats ; Abstract ; Introduction ; Materials and Methods ; Animals ; Methods. In vivo 31P Magnetic Resonance Spectroscopy In Vitro Mitochondrial Respiration ; In Vitro Mitochondrial Oxidative Phosphorylation (Table 2 and Figure 2) ; Endogenous Antioxidants ; Statistical Methods ; Results ; In Vivo 31P Magnetic Resonance Spectroscopy ; Endogenous Antioxidants (Table 3 and Figure 3) ; Discussion ; Acknowledgments ; References ; The Pathophysiology of Cerebrovascular Lesions in Alzheimer Disease ; Abstract ; The Effect of Oxidative Stress on Brain Microvessel Function in AD ; Neuropathologic Features of Cerebrovascular Lesions. Hypoperfusion as a Factor in the Development of AD Relationships between Apolipoprotein E (ApoE) Genotype, Hypercholesterolemia, and Vascular Changes in AD ; Hypoxia/Ischemia/Reperfusion as Cofactors for Oxidative Stress Induced Cerebrovascular Lesions and their Relationship to AD ; The Role of Mitochondrial Abnormalities in the Patho-Genesis of Oxidative Stress-Induced Brain Lesions in AD ; The Role of Endothelial Vasoactive Substancesin the Pathophysiology of Brain Ischemia/Reperfusion and AD ; Transgenic Animals as Models for Studying Cerebrovascular Lesions in AD. Prevention of AD Using Selective Pharmacological Treatments Conclusion and Considerations for the Future; Acknowledgments ; References ; Vascular Pathology in the Pathogenesis of Alzheimer Disease ; I. Epidemiological Findings ; II. Elements of Brain Tissue Metabolism; III. Causes and Risk Factors ; Inflammatory System ; Vascular Pathology ; 1. Mitochondrial Dysfunction in AD ; 2. Hypoxia and AD ; 3. History of Stroke, Cerebral Ischemia and AD ; 4. Hypertension and Alzheimer Disease ; Acknowledgments ; References. Oxidative Stress Induced Mitochondrial Failure and Cellular Hypoperfusion as Primary Pathogenic Factors for the Development and Progression of Alzheimer Disease Abstract ; Introduction ; Cerebral Vascular Energy Requirements: Hypoperfusion as a Key Factor for the Development of AD ; The Effect of Oxidative Stress on Brain Microvessel Function and A
9781619428973 1619428970
2020678324
016063297 Uk
Alzheimer's disease.
Oxidative stress.
Mitochondrial pathology.
Cell respiration.
London Health Libraries Consortium Privacy notice and Membership terms and conditions