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The Systemic Effects of Advanced Cancer (Record no. 100535)

MARC details
000 -LEADER
fixed length control field 04414nam a22004935i 4500
001 - CONTROL NUMBER
control field 978-3-031-09518-4
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240729133541.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 220921s2022 sz | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783031095184
-- 978-3-031-09518-4
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCL
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED062000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCL
Source thema
245 14 - TITLE STATEMENT
Title The Systemic Effects of Advanced Cancer
Subtitle : A Textbook on Cancer-Associated Cachexia /
250 ## - EDITION
Edition statement 1st ed. 2022.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Cham :
Name of producer, publisher, distributor, manufacturer Springer International Publishing :
-- Imprint: Springer,
Date of production, publication, distribution, manufacture, or copyright notice 2022.
300 ## - PHYSICAL DESCRIPTION
Physical description VI, 203 p. 1 illus.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
505 0# - CONTENTS
Contents Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.
520 ## - ABSTRACT
Abstract This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
650 #0 - SUBJECT HEADINGS
Subject term Cancer.
650 #0 - SUBJECT HEADINGS
Subject term Oncology.
9 (RLIN) 13364
650 #0 - SUBJECT HEADINGS
Subject term Immunology.
650 #0 - SUBJECT HEADINGS
Subject term Metastasis.
650 #0 - SUBJECT HEADINGS
Subject term Cytology.
650 14 - SUBJECT HEADINGS
Subject term Cancer Biology.
650 24 - SUBJECT HEADINGS
Subject term Oncology.
9 (RLIN) 13364
650 24 - SUBJECT HEADINGS
Subject term Immunology.
650 24 - SUBJECT HEADINGS
Subject term Metastasis.
650 24 - SUBJECT HEADINGS
Subject term Cell Biology.
700 1# - ADDED PERSONAL NAME
Added personal author Acharyya, Swarnali.
Relator term editor.
710 2# - ADDED CORPORATE NAME
Added corporate author SpringerLink (Online service)
856 ## - ONLINE RESOURCE
Uniform Resource Identifier <a href="#gotoholdings">#gotoholdings</a>
Link text Access resource
245 ## - TITLE STATEMENT
Medium [E-Book]
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
912 ## -
-- ZDB-2-SBL
912 ## -
-- ZDB-2-SXB
Holdings
Withdrawn status Lost status Damaged status Not for loan Home library Current library Shelving location Date acquired Source of acquisition Total Checkouts Date last seen Uniform Resource Identifier Price effective from Koha item type
        Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Online 02/05/2024 Springer BiomedLifeSc   02/05/2024 https://go.openathens.net/redirector/nhs?url=https://doi.org/10.1007/978-3-031-09518-4 02/05/2024 Electronic book
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