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Single Nucleotide Polymorphisms (Record no. 100888)

MARC details
000 -LEADER
fixed length control field 04445nam a22004575i 4500
001 - CONTROL NUMBER
control field 978-3-031-05616-1
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240729133901.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 220808s2022 sz | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783031056161
-- 978-3-031-05616-1
072 #7 - SUBJECT CATEGORY CODE
Subject category code MFN
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED107000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code MFN
Source thema
245 10 - TITLE STATEMENT
Title Single Nucleotide Polymorphisms
Subtitle : Human Variation and a Coming Revolution in Biology and Medicine /
250 ## - EDITION
Edition statement 1st ed. 2022.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Cham :
Name of producer, publisher, distributor, manufacturer Springer International Publishing :
-- Imprint: Springer,
Date of production, publication, distribution, manufacture, or copyright notice 2022.
300 ## - PHYSICAL DESCRIPTION
Physical description XVIII, 234 p. 23 illus., 20 illus. in color.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
505 0# - CONTENTS
Contents SECTION I -- Chapter 1: Evolutionary Forces that Generate SNPs -- Chapter 2: Conserved SNPs: Providing Answers to Fundamental Questions in Human Biology -- Chapter 3: SNPs Classification and Terminology -- SECTION II -- Chapter 4: SNPs Ability to Influence Disease Risk -- Chapter 5: GWAS to Identify SNPs Associated with Common Diseases and Individual Risk -- SECTION III -- Chapter 6: A Case Study of Molecular Mechanisms by Which Non-Synonymous SNPs Alter Protein Structure and Function -- Chapter 7: A Case Study of Molecular Mechanisms by Which Synonymous SNPs Alter Protein Structure and Function -- SECTION IV -- Chapter 8: Using Genome-Wide Studies to Study Synonymous Codons -- Chapter 9: Bioinformatics Tools for Identification of SNPs -- Chapter 10: Bionformatic Tools for Predicting SNPs Effects on Gene Function and Phenotype -- Chapter 11: New Biophysical Techniques for Single mRNA Molecule Measurements -- Chapter 12: Emerging Mechanisms by Which Synonymous Mutations Affect Protein Folding, Protein Function and Physiological Changes -- SECTION V -- Chapter 13: SNPs and Personalized Medicine -- Chapter 14: Distribution of SNPs Associated with Personality Traits -- Chapter 15: Condon Optimization.
520 ## - ABSTRACT
Abstract This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor intensive, expensive, time-consuming processes to relatively inexpensive methods, SNP discovery has exploded. In terms of human biology, this research, particularly since the completion of the Human Genome Project, has provided a detailed understanding of evolutionary forces that have generated SNPs. It also has shown how SNPs shape human variation. The ability to inexpensively generate and analyze vast amounts of genetic data is poised to transform our understanding of human evolution and biology. "Single Nucleotide Polymorphisms" covers a broad survey of SNPs and their classification into synonymous and non-synonymous; the role of SNPs in human disease; case studies providing specific examples of synonymous and non-synonymous SNPs associated with human diseases or affecting therapeutic interventions; mechanisms by which synonymous mutations affect protein levels or protein folding which affect human physiology and response to therapy; and the role of SNPs in personalized medicine. Understanding what SNPs are, how they have been shaped is necessary for an increasingly expanding audience. This research will revolutionize the future of medicine. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. SNPs Ability to Influence Disease Risk: Breaking the Silence on Synonymous Mutations in Cancer" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
650 #0 - SUBJECT HEADINGS
Subject term Medical genetics.
650 #0 - SUBJECT HEADINGS
Subject term Cytology.
650 #0 - SUBJECT HEADINGS
Subject term Bioinformatics.
650 14 - SUBJECT HEADINGS
Subject term Medical Genetics.
650 24 - SUBJECT HEADINGS
Subject term Cell Biology.
650 24 - SUBJECT HEADINGS
Subject term Bioinformatics.
700 1# - ADDED PERSONAL NAME
Added personal author Sauna, Zuben E.
Relator term editor.
700 1# - ADDED PERSONAL NAME
Added personal author Kimchi-Sarfaty, Chava.
Relator term editor.
710 2# - ADDED CORPORATE NAME
Added corporate author SpringerLink (Online service)
856 ## - ONLINE RESOURCE
Uniform Resource Identifier <a href="#gotoholdings">#gotoholdings</a>
Link text Access resource
245 ## - TITLE STATEMENT
Medium [E-Book]
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
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-- ZDB-2-SBL
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-- ZDB-2-SXB
Holdings
Withdrawn status Lost status Damaged status Not for loan Home library Current library Shelving location Date acquired Source of acquisition Total Checkouts Date last seen Uniform Resource Identifier Price effective from Koha item type
        Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Online 02/05/2024 Springer BiomedLifeSc   02/05/2024 https://go.openathens.net/redirector/nhs?url=https://doi.org/10.1007/978-3-031-05616-1 02/05/2024 Electronic book
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