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PI3K and AKT Isoforms in Immunity (Record no. 101188)

MARC details
000 -LEADER
fixed length control field 03877nam a22005295i 4500
001 - CONTROL NUMBER
control field 978-3-031-06566-8
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240729134155.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 221015s2022 sz | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783031065668
-- 978-3-031-06566-8
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCM
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code MED044000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code MJCM
Source thema
245 10 - TITLE STATEMENT
Title PI3K and AKT Isoforms in Immunity
Subtitle : Mechanisms and Therapeutic Opportunities /
250 ## - EDITION
Edition statement 1st ed. 2022.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Cham :
Name of producer, publisher, distributor, manufacturer Springer International Publishing :
-- Imprint: Springer,
Date of production, publication, distribution, manufacture, or copyright notice 2022.
300 ## - PHYSICAL DESCRIPTION
Physical description VII, 466 p. 42 illus., 37 illus. in color.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
490 1# - SERIES TITLE
Series statement Current Topics in Microbiology and Immunology,
International Standard Serial Number 2196-9965 ;
Volume 436
505 0# - CONTENTS
Contents Class I PI3K biology -- Class II PI3K biology -- Class III PI3K biology -- PTEN in immunity -- PHLPP Signaling in Immune Cells -- PHLPP Signaling in Immune Cells -- PI3K isoforms in cell signalling and innate immune cell responses -- AKT isoforms in macrophage activation, polarization and survival -- Control of CD4+ T cell Differentiation and Function by PI3K isoforms. -- PI3K isoforms in CD8+ T cell development and function -- PI3K isoforms in B cells -- PI3K isoform signalling in platelets -- PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection -- PI3K and AKT at the Interface of Signaling and Metabolism -- The Role of PI3K Isoforms in Autoimmune Disease -- AKT Isoforms in the Immune Response in Cancer -- PI3K isoform immunotherapy for solid tumours -- PI3K targeting in non-solid cancer -- AKT isoforms as a target in cancer and immunotherapy -- Developing PI3K Inhibitors for Respiratory Diseases.
520 ## - ABSTRACT
Abstract This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body's own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
650 #0 - SUBJECT HEADINGS
Subject term Immunology.
650 #0 - SUBJECT HEADINGS
Subject term Immune system.
9 (RLIN) 6566
650 #0 - SUBJECT HEADINGS
Subject term Cellular signal transduction.
650 #0 - SUBJECT HEADINGS
Subject term Cytology.
650 #0 - SUBJECT HEADINGS
Subject term Autoimmunity.
650 #0 - SUBJECT HEADINGS
Subject term Immunospecificity.
650 14 - SUBJECT HEADINGS
Subject term Immunology.
650 24 - SUBJECT HEADINGS
Subject term Immune Cell Signalling.
650 24 - SUBJECT HEADINGS
Subject term Cell Biology.
650 24 - SUBJECT HEADINGS
Subject term Autoimmunity.
650 24 - SUBJECT HEADINGS
Subject term Adaptive Immunity.
700 1# - ADDED PERSONAL NAME
Added personal author Dominguez-Villar, Margarita.
Relator term editor.
710 2# - ADDED CORPORATE NAME
Added corporate author SpringerLink (Online service)
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Current Topics in Microbiology and Immunology,
International Standard Serial Number 2196-9965 ;
Volume number/sequential designation 436
856 ## - ONLINE RESOURCE
Uniform Resource Identifier <a href="#gotoholdings">#gotoholdings</a>
Link text Access resource
245 ## - TITLE STATEMENT
Medium [E-Book]
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
912 ## -
-- ZDB-2-SBL
912 ## -
-- ZDB-2-SXB
Holdings
Withdrawn status Lost status Damaged status Not for loan Home library Current library Shelving location Date acquired Source of acquisition Total Checkouts Date last seen Uniform Resource Identifier Price effective from Koha item type
        Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Online 02/05/2024 Springer BiomedLifeSc   02/05/2024 https://go.openathens.net/redirector/nhs?url=https://doi.org/10.1007/978-3-031-06566-8 02/05/2024 Electronic book
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