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Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine (Record no. 101230)

MARC details
000 -LEADER
fixed length control field 06466nam a22005775i 4500
001 - CONTROL NUMBER
control field 978-3-031-06573-6
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240729134218.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 221108s2022 sz | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9783031065736
-- 978-3-031-06573-6
072 #7 - SUBJECT CATEGORY CODE
Subject category code PSD
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code PSF
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code SCI049000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code PSD
Source thema
072 #7 - SUBJECT CATEGORY CODE
Subject category code PSF
Source thema
245 10 - TITLE STATEMENT
Title Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine
250 ## - EDITION
Edition statement 1st ed. 2022.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Cham :
Name of producer, publisher, distributor, manufacturer Springer International Publishing :
-- Imprint: Springer,
Date of production, publication, distribution, manufacture, or copyright notice 2022.
300 ## - PHYSICAL DESCRIPTION
Physical description XI, 663 p. 1 illus.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
490 1# - SERIES TITLE
Series statement Results and Problems in Cell Differentiation,
International Standard Serial Number 1861-0412 ;
Volume 70
505 0# - CONTENTS
Contents Part I. Genome Architecture, Evolution, and Cell Fate -- Chapter 1. Networks and Islands of Genome Nano-Architecture and their Potential Relevance for Radiation Biology (A Hypothesis and Experimental Verification Hints) -- Chapter 2. A Unified Genomic Mechanism of Cell-Fate Change -- Chapter 3. Alterations to Genome Organisation in Stem Cells, Their Differentiation and Associated Diseases -- Chapter 4. How Genomes Emerge, Function, and Evolve: Living Systems Emergence - Genotype-Phenotype-Multilism - Genome/Systems Ecology -- Chapter 5. Integrating Multimorbidity into a Whole-Body Understanding of Disease Using Spatial Genomics -- Part II. Chromosomes and Chromatin Architecture and Dynamics -- Chapter 6. Mitotic Antipairing of Homologous Chromosomes -- Chapter 7. CENP-A, a Histone H3 Variant with Key Roles in Centromere Architecture in Healthy and Diseased States -- Chapter 8. Scaling Relationship in Chromatin as a Polymer -- Chapter 9. Chromatin Dynamics during Entry toQuiescence and Compromised Functionality in Cancer Cells -- Chapter 10. Functional Aspects of Sperm Chromatin Organization -- Part III. Mechanosensitive and Epigenetic Regulators of Gene Expression and Chromatin Organization -- Chapter 11. The LINC Complex Assists the Nuclear Import of Mechanosensitive Transcriptional Regulators -- Chapter 12. Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Cell and Tissue Structure, Function, and Phenotype -- Chapter 13. Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle -- Chapter 14. Histone Modifications in Mouse Pronuclei and Consequences for Embryo Development -- Part IV. Nucleus, Nucleolus, and Nucleolar Organizer Architecture -- Chapter 15. Nuclear Architecture in the Nervous System -- Chapter 16. Nuclear Morphological Abnormalities in Cancer: A Search for Unifying Mechanisms -- Chapter 17. Nuclear Organization in Response to Stress: A Special Focus on Nucleoli -- Chapter 18. Simulation of Different Three-Dimensional Models of Whole Interphase Nuclei Compared to Experiment - A Consistent Scale-Bridging Simulation Framework for Genome Organization -- Chapter 19. Nucleolar Organizer Regions as Transcription-Based Scaffolds of Nucleolar Structure and Function -- Chapter 20. A Transient Mystery: Nucleolar Channel Systems -- Part V. Nuclear Actin Role in Polarization, Genome Organization, and Gene Expression -- Chapter 21. Cellular Polarity Transmission to the Nucleus -- Chapter 22. The Role of Nuclear Actin in Genome Organization and Gene Expression Regulation During Differentiation -- Chapter 23. Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer.
520 ## - ABSTRACT
Abstract This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability ofthe genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.
650 #0 - SUBJECT HEADINGS
Subject term Cell nuclei.
650 #0 - SUBJECT HEADINGS
Subject term Chromosomes.
9 (RLIN) 5619
650 #0 - SUBJECT HEADINGS
Subject term Biology
General subdivision Technique.
650 #0 - SUBJECT HEADINGS
Subject term Genomics.
650 #0 - SUBJECT HEADINGS
Subject term Biomaterials.
650 #0 - SUBJECT HEADINGS
Subject term Nucleic acids.
9 (RLIN) 7168
650 #0 - SUBJECT HEADINGS
Subject term Gene expression.
650 14 - SUBJECT HEADINGS
Subject term Nuclear Organization.
650 24 - SUBJECT HEADINGS
Subject term Chromosomes.
9 (RLIN) 5619
650 24 - SUBJECT HEADINGS
Subject term Genomic Analysis.
650 24 - SUBJECT HEADINGS
Subject term Nucleic Acid.
650 24 - SUBJECT HEADINGS
Subject term Gene Expression Analysis.
700 1# - ADDED PERSONAL NAME
Added personal author Kloc, Malgorzata.
Relator term editor.
700 1# - ADDED PERSONAL NAME
Added personal author Kubiak, Jacek Z.
Relator term editor.
710 2# - ADDED CORPORATE NAME
Added corporate author SpringerLink (Online service)
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE
Uniform title Results and Problems in Cell Differentiation,
International Standard Serial Number 1861-0412 ;
Volume number/sequential designation 70
856 ## - ONLINE RESOURCE
Uniform Resource Identifier <a href="#gotoholdings">#gotoholdings</a>
Link text Access resource
245 ## - TITLE STATEMENT
Medium [E-Book]
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
912 ## -
-- ZDB-2-SBL
912 ## -
-- ZDB-2-SXB
Holdings
Withdrawn status Lost status Damaged status Not for loan Home library Current library Shelving location Date acquired Source of acquisition Total Checkouts Date last seen Uniform Resource Identifier Price effective from Koha item type
        Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Online 02/05/2024 Springer BiomedLifeSc   02/05/2024 https://go.openathens.net/redirector/nhs?url=https://doi.org/10.1007/978-3-031-06573-6 02/05/2024 Electronic book
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