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Phase Separation in Living Cells (Record no. 103745)

MARC details
000 -LEADER
fixed length control field 05394nam a22005295i 4500
001 - CONTROL NUMBER
control field 978-981-99-4886-4
003 - CONTROL NUMBER IDENTIFIER
control field DE-He213
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240729140244.0
007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION
fixed length control field cr nn 008mamaa
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 230929s2023 si | s |||| 0|eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
ISBN 9789819948864
-- 978-981-99-4886-4
072 #7 - SUBJECT CATEGORY CODE
Subject category code PSD
Source bicssc
072 #7 - SUBJECT CATEGORY CODE
Subject category code SCI007000
Source bisacsh
072 #7 - SUBJECT CATEGORY CODE
Subject category code PSD
Source thema
245 10 - TITLE STATEMENT
Title Phase Separation in Living Cells
Subtitle : Benefits and Risks /
250 ## - EDITION
Edition statement 1st ed. 2023.
264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Place of production, publication, distribution, manufacture Singapore :
Name of producer, publisher, distributor, manufacturer Springer Nature Singapore :
-- Imprint: Springer,
Date of production, publication, distribution, manufacture, or copyright notice 2023.
300 ## - PHYSICAL DESCRIPTION
Physical description VIII, 318 p. 1 illus.
Other physical details online resource.
336 ## - CONTENT TYPE
Content type term text
Content type code txt
Source rdacontent
337 ## - MEDIA TYPE
Media type term computer
Media type code c
Source rdamedia
338 ## - CARRIER TYPE
Carrier type term online resource
Carrier type code cr
Source rdacarrier
505 0# - CONTENTS
Contents Chapter 1. FUS aggregation by shear stress on pipetting and its suppression by non-coding RNA -- Chapter 2. Basics and recent advances in computational and theoretical methods for understanding the liquid-liquid phase separation -- Chapter 3.Promotion of liquid-liquid phase separation by G-quadruplex DNA and RNA -- Chapter 4. Phase regulation by chaperons -- Chapter 5. Regulation of aggregation of intrinsically disordered protein through phase separation: Risk management of phase separation -- Chapter 6. Molecular mechanisms of phase transition/separation of protein low-complexity sequences -- Chapter 7. Winding and Tangling. An Initial Phase of Membrane-less Organelle Formation (from a viewpoint of Cajal Bodies) -- Chapter 8. Formation and function of phase separated nuclear bodies directed by architectural noncoding RNA -- Chapter 9. Force-dependent remodeling of cell-to-cell adhesion through the regulation of phase separation -- Chapter 10. Neuronal RNA granules: Phase separation, dynamics, and higher brain functions -- Chapter 11. Liquid-liquid phase separation in structure and function of nuclear pore complex -- Chapter 12. Phase Separation Orchestrates Cancer Signaling: Biomolecular condensates as a promising target for cancer therapy -- Chapter 13. Regulatory interaction of intrinsically disordered regions of pathogenic proteins in neurodegenerative diseases -- Chapter 14. Functional properties of phase separation and intranuclear complex of FUS in the pathogenesis of ALS/FTLD -- Chapter 15. Functional responses of microglia to amyloid plaques -- Chapter 16. Emerging role of phage separation in COVID-19.
520 ## - ABSTRACT
Abstract This book presents the latest cutting-edge research on phase separation. It discusses the benefits and risks of phase separation for living cells from the perspectives of physics, chemistry, biology, and medicine. Phase separation is a physico-chemical process that induces a single solution of solvent and intrinsically disordered proteins (IDPs) to separate into two phases, one phase containing only solvent and the other containing IDPs in the solvent. A key molecule in phase separation is the intrinsically disordered region (IDR) proteins (IDPs), mostly comprised of RNA-binding proteins (RBPs). One of the major roles of phase separation is to generate condensates, membrane-less organelles including stress granule, Cajal body, and nucleolus. Biological actions of phase separation in various aspects of science have received increasing attention in recent years. The book consists of four parts; Part I on physics and chemistry includes topics on structural biology of RBP FUS/TLS and chaperone for phase separation, computational approach of phase separation, and chemistry of G-quadruplex of DNA and RNA. Part II on molecular biology presents molecular mechanism of IDR sequence phase separation and potential cellular function of these labile fibers, formation of membrane-less organelles, and roles of noncoding RNAs in phase separation. Part III on biology covers topics from nuclear pore complex, developmental biology regarding force-dependent remodeling, and neurobiology and higher order brain functions. Finally, Part IV on medicine presents condensates and cancer therapy, pathogenesis of neurodegenerative diseases based on IDPs, and responses of microglia to amyloid. The last chapter highlights the latest topic on how the SARS-Cov-2 virus takes advantage of phase separation for its infections. This book brings together the studies of phase separation in each area in a single volume. The comprehensive approach provides new insights to the research and will benefit the readers by responding to the emerging needs for understanding phase separation.
650 #0 - SUBJECT HEADINGS
Subject term Molecular biology.
9 (RLIN) 7018
650 #0 - SUBJECT HEADINGS
Subject term Biophysics.
9 (RLIN) 5390
650 #0 - SUBJECT HEADINGS
Subject term Medicine
General subdivision Research.
650 #0 - SUBJECT HEADINGS
Subject term Biology
General subdivision Research.
650 #0 - SUBJECT HEADINGS
Subject term Cytology.
650 #0 - SUBJECT HEADINGS
Subject term Biochemistry.
650 #0 - SUBJECT HEADINGS
Subject term Non-coding RNA.
650 14 - SUBJECT HEADINGS
Subject term Molecular Biology.
9 (RLIN) 7018
650 24 - SUBJECT HEADINGS
Subject term Biophysics.
9 (RLIN) 5390
650 24 - SUBJECT HEADINGS
Subject term Biomedical Research.
650 24 - SUBJECT HEADINGS
Subject term Cell Biology.
650 24 - SUBJECT HEADINGS
Subject term Biochemistry.
650 24 - SUBJECT HEADINGS
Subject term Non-coding RNAs.
700 1# - ADDED PERSONAL NAME
Added personal author Kurokawa, Riki.
Relator term editor.
710 2# - ADDED CORPORATE NAME
Added corporate author SpringerLink (Online service)
856 ## - ONLINE RESOURCE
Uniform Resource Identifier <a href="#gotoholdings">#gotoholdings</a>
Link text Access resource
245 ## - TITLE STATEMENT
Medium [E-Book]
347 ## - DIGITAL FILE CHARACTERISTICS
File type text file
Encoding format PDF
Source rda
912 ## -
-- ZDB-2-SBL
912 ## -
-- ZDB-2-SXB
Holdings
Withdrawn status Lost status Damaged status Not for loan Home library Current library Shelving location Date acquired Source of acquisition Total Checkouts Date last seen Uniform Resource Identifier Price effective from Koha item type
        Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Hillingdon Hospitals Library Services (Hillingdon Hospitals NHS Foundation) Online 02/05/2024 Springer BiomedLifeSc_2023   02/05/2024 https://go.openathens.net/redirector/nhs?url=https://doi.org/10.1007/978-981-99-4886-4 02/05/2024 Electronic book
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