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Frequency and significance of indeterminate and borderline Quantiferon Gold TB IGRA results (Record no. 76380)

MARC details
000 -LEADER
fixed length control field 01854cam a2200169 4500
001 - CONTROL NUMBER
control field NMDX7514
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 120401t2017 xxu||||| |||| 00| 0 eng d
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Kumar, K.
240 ## - UNIFORM TITLE
Uniform title <a href="European Respiratory Journal">European Respiratory Journal</a>
245 ## - TITLE STATEMENT
Title Frequency and significance of indeterminate and borderline Quantiferon Gold TB IGRA results
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc. 2017
500 ## - GENERAL NOTE
General note NMUH Staff Publications
500 ## - GENERAL NOTE
General note 50
520 ## - SUMMARY, ETC.
Summary, etc. &lt;span style="font-size: 10pt;"&gt;The Quantiferon Gold test is one of two commercially available tuberculosis (TB) interferon-γ release assays (IGRAs) recommended for the diagnosis of latent TB infection. A Quantiferon Gold test is considered positive if the result is ≥0.35 IU·mL&lt;/span&gt;&lt;sup&gt;&lt;span style="font-size: 10pt;"&gt;−1&lt;/span&gt;&lt;/sup&gt;&lt;span style="font-size: 10pt;"&gt;. However, longitudinal studies have shown that a significant number of test reversions and conversions occur if results just above or below this threshold are repeated. This variation may be due to random chance or other factors such as test-related errors, differences in absolute lymphocyte numbers and within-subject variability of the interferon-γ response. The high proportion of conversions and reversions around the 0.35 IU·mL&lt;/span&gt;&lt;sup&gt;&lt;span style="font-size: 10pt;"&gt;−1&lt;/span&gt;&lt;/sup&gt;&lt;span style="font-size: 10pt;"&gt; cut-off has led some to suggest that a borderline or equivocal range should be used, as this avoids treatment of individuals who do not have a ‘stable’ positive result, as well as failure to treat those just below the 0.35 threshold who would convert to a positive result if the test were repeated.&amp;nbsp;&lt;/span&gt;
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://erj.ersjournals.com/content/50/4/1701267.long">http://erj.ersjournals.com/content/50/4/1701267.long</a>
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://ferriman.wufoo.com/forms/journal-article-request/">http://ferriman.wufoo.com/forms/journal-article-request/</a>
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        Staff publications for NMDX Ferriman Information and Library Service (North Middlesex) Ferriman Information and Library Service (North Middlesex) Online 07/06/2022   07/06/2022 07/06/2022 UNKNOWN