High Altitude Sickness - Solutions from Genomics, Proteomics and Antioxidant Interventions [E-Book]

1 Introduction to High Altitude and Hypoxia -- 2 High altitude sickness: environmental stressor and altered physiological response -- 3 High-Altitude Related Diseases: Milder Effects, HACE, HAPE, and Effect on Various Organ Systems -- 4 High altitude-induced Oxidative stress, Rheumatoid Arthritis and proteomic alteration -- 5 Oxidative Stress, ROS generation and Associated Molecular Alterations in High Altitude Hypoxia -- 6 Oxidative Stress, ROS generation and Associated Molecular Alterations in High Altitude Hypoxia -- 7 Current problems in diagnosis and treatment of high altitude sickness -- 8 Proteomics as a potential tool for biomarker discovery -- 9 Serum and Plasma Proteomics for High-Altitude Related Biomarker Discovery -- 10 Saliva Proteomics As Non-Invasive Application For Biomarker Studies -- 11 Role of genomics, proteomics and antioxidant interventions in preventing High Altitude Sickness -- 12 High Altitude Sickness AndAntioxidant Interventions -- 13 Antioxidant therapy for high altitude sickness and Nano-medicine.

This book reviews the recent advances in the development of proteomics-based biomarkers for the non-invasive diagnosis of altitude sickness and explores the potential of antioxidant therapy for this sickness. The first chapters introduce the associated pathophysiology and provide mechanistic insights into the enhanced generation of reactive oxygen and nitrogen species (RONS), which leads to an increase in oxidative damage to lipids, proteins, and DNA. The book then highlights the current problems relating to the diagnosis and treatment of altitude sickness and summarizes novel approaches for identifying potential biomarkers and therapeutics. Lastly, it explores the therapeutic efficacy of antioxidant agents.