Natural Products from Actinomycetes : Diversity, Ecology and Drug Discovery / [E-Book]

Chapter 1. Dimensional Research on Actinomycetes -- Chapter 2. Isolation of Actinobacteria from uncommon habitats like insects and mollusks -- Chapter 3. Diversity, Chemical biology and Ecology of Actinomycetes and the Discovery of Natural Products -- Chapter 4. Actinobacteria from Arid Environments and their Biotechnological Applications -- Chapter 5. Endophytic actinobacteria in biosynthesis of bioactive metabolites and their application in improving crop yield and sustainable agriculture -- Chapter 6. An overview on natural product from endophytic actinomycetes -- Chapter 7. Regulation of Secondary Metabolites through Signaling Moleculesin Streptomyces -- Chapter 8. New strategies to activate secondary metabolism in Streptomyces -- Chapter 9. Novel Agroactive Secondary Metabolites from Actinomycetes in The Past Two Decades with Focus on Screening Strategies and Discovery -- Chapter 10. Quorum sensing and quorum quenching Metabolites in Actinomycetes -- Chapter 11. Metabolic engineering of Actinomycetes for natural product discovery -- Chapter 12. Application of CRISPR Cas9 editing for production of secondary metabolites in actinomycetes -- Chapter 13. Synthetic biology in actinomycetes for natural product discovery -- Chapter 14. Endophytic actinomycetes: secondary metabolites and genomic approaches -- Chapter 15. Mining for NRPS and PKS genes in Actinobacteria using Whole-genome sequencing and Bioinformatics Tools -- Chapter 16. Glycopeptide antibiotics: genetics, chemistry, new screening approaches -- Chapter 17. Biotechnological aspects of siderophore biosynthesis by actinobacteria -- Chapter 18. An overview of biomedical, biotechnological and industrial applications of Actinomycetes.-.

This book provides in-depth information about the ecology, diversity and applications of Actinomycetes. The book is divided into two major parts. The first part discusses the diversity, chemical biology and ecology of Actinomycetes. It also covers the discovery of natural products from soil, endophytic and marine-derived Actinomycetes. It includes natural product discovery, chemical biology, new methods for discovering secondary metabolites, structure elucidation and biosynthetic research of natural products. The chapters in this part focus on the effects of biological and chemical elicitation at molecular level on secondary metabolism in Actinomycetes. The second part of the book discusses genomic and synthetic biology approaches in Actinomycetes drug discovery. This part includes chapters focused on the application of metabolic engineering to optimize natural product synthesis and the use of omics data in engineering of regulatory genes. It covers the advanced tools of synthetic biology and metabolic engineering including cluster assembly, CRISPR/Cas9 technologies, and chassis strain development for natural product overproduction in Actinomycetes. It describes the use of bioinformatics tools for reprogramming of biosynthetic pathways through polyketide synthase and non-ribosomal peptide synthetase engineering. These advanced genomic and molecular tools are expected to accelerate the discovery and development of new natural products from Actinomycetes with medicinal and other industrial applications. The book is useful to researchers and students in the field of microbiology, pharmaceutical sciences and drug discovery.