Microbial Production of High-Value Products [E-Book]

Advancements in Inducer Systems for Recombinant Protein Production in E. Coli -- Microbial Biosynthesis of Straight-Chain Aliphatic Carboxylic Acids -- Microbial Production of Amines and Amino Acids by Fermentation -- Strategies for Improving Biotherapeutic Protein Production in Microbial Cell Factories -- Current Trends and Prospects in Antimicrobial Peptide Bioprocessing -- Bioproduction of Cyclic Disulfide Rich Peptides for Drug Modalities -- Hyaluronic Acid (Hyaluronan) -- Polyhydroxyalkanoates (PHA): Microbial Synthesis of Natural Polyesters -- Recent Advances in Poly-(γ-Glutamic Acid) Production by Microbial Fermentation -- Bioengineering and Bioprocessing of Virus-Like Particle Vaccines in Escherichia Coli -- Functional Inclusion Bodies -- Encapsulin Nanocompartments for Biomanufacturing Applications -- Lumazine Synthase Nanocompartments.

This edited volume emphasizes how microorganisms have become a reliable pillar of biotechnology. The authors discuss advances in synthetic biology and genetic engineering that have made it possible to reprogram the microbial cellular capabilities. This enables an economically viable production of high-value products at an industrial level. The first part of the book provides an overview of synthetic biology and genome editing tools for engineering microbial cell factories in modern fermentation. Readers also learn how high-throughput bioprocessing methods are used to recover and purify microbial products. The remaining parts of this book explore the implementation and challenges of these upstream and downstream processing techniques for manufacturing high-value products. Cost-effectiveness and quality-control are key factors, when discussing the production of low-molecular-weight products, biopharmaceuticals, biopolymers and protein-based nanoparticles. This book is a valuable resource for biotechnologists both in the industry and in academia.