Microbiome in Gastrointestinal Cancer [E-Book]

Introduction -- Gut microbiome in health and diseases -- Microbiome in colorectal cancer -- Microbiome in gastric cancer -- Microbiome in liver cancer -- Virus, fungi and archaea in gastrointestinal cancer -- Microbial metabolomics in gastrointestinal cancer -- Diet and gut microbiome in gastrointestinal cancer -- Diet and gut microbiome in fatty liver and its associated liver cancer -- Host-microbiome interaction in gastrointestinal cancer -- Gut microbiome and immune responses in gastrointestinal cancer -- Animal models in the study of microbiome in gastrointestinal cancer -- High-throughput sequencing data analyses for microbiome profiling -- Gut microbiota modulation: probiotics and prebiotics in gastrointestinal cancer -- Roles of gut microbiota in efficacy of anticancer treatment of gastrointestinal cancer -- Targeting gut microbiota to treat gastrointestinal cancer.

This book covers state-of-the-art topics covering evidences indicate that the gut microbiota can be harnessed for cancer prevention as well as to modulate the efficacy of chemotherapy and immunotherapy. This book includes: 1) characterization of the dysregulated microbiome in gastrointestinal cancers (Chapters 1-6); 2) the molecular mechanism of action of gut microbiota via microbial metabolites and direct interaction with host cancer or immune cells (Chapters 7-11); 3) key methodologies for studying the role of gut microbiota in cancers (Chapters 12-13); and 4) the potential application of gut microbes for the prevention and treatment of gastrointestinal cancers (Chapters 14-17). The contributors are international experts in molecular and cellular biology, microbiology, metabolomics, bioinformatics and physician scientists to provide in-depth reviews of this subject. This book provides a rich resource of information on this important topic for graduate students, basic researchers and physicians.