Epigenetics in Oncology [E-Book]

PART I RNA Epigenetics, RNA modifications in cancer metabolism and tumor microenvironment -- RNA modifications in cancer stem cell biology -- Recent advances of RNA m6A modifications in cancer immunoediting and immunotherapy -- Recent advances in RNA m6A modification in solid tumors and tumor immunity -- Recent advances in adenosine-to-inosine RNA editing in cancer -- RNA modification in hematopoietic malignancies -- PART II Histone Epigenetics, The SWI/SNF complex: A frequently-mutated chromatin remodelling complex in cancer -- Histone readers and their roles in cancer -- Polycomb repressive complex 2 in oncology -- Epigenetic (de)regulation in prostate cancer -- PART III DNA Epigenetics, TET methylcytosine dioxygenases in cancer -- Inferring the cancer cellular epigenome heterogeneity via DNA methylation patterns.

This book addresses Epigenetics in Cancer and covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years. Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resourcefor scientists, graduate students and clinicians alike. .