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Next generation antidepressants : moving beyond monoamines to discover novel treatment strategies for mood disorders / [E-Book]

Contributor(s):

Series: Cambridge medicine (Series)Publisher: Cambridge : Cambridge University Press, 2010Description: 1 online resource (xi, 137 pages)ISBN:

9780521760584 (hardback)
9780511778414 (ebook)
9781139832571 (ebook)

Subject(s):

NLM classification:

WM 402.

Contents:

1 Current depression landscape: a state of the field today Laurence Mignon and Stephen M. Stahl 2 Novel therapeutic targets for treating affective disorders Eliyahu Dremencov and Thomas Cremers 3 Developing novel animal models of depression Lotte de Groote and Malgorzata Filip and Andrew C. McCreary 4 Translational research in mood disorders: using imaging technologies in biomarker research Jul Lea Shamy and Adam M. Brickman and Chris D. Griesemer and Anna Parachikova and Mark Day 5 Defining depression endophenotypes Lisa H. Berghorst and Diego A. Pizzagalli 6 Genetic and genomic studies of major depressive disorder Roy H. Perlis 7 Medicinal chemistry challenges in the design of next generation antidepressants David P. Rotella 8 Application of pharmacogenomics and personalized medicine for the care of depression Keh-Ming Lin and Chun-Yu Chen and Yu-Jui Yvonne Wan

Summary: The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This is essential reading for all those involved in psychopharmacologic drug development, and mental health clinicians seeking a preview of discoveries soon to influence their practice.

List(s) this item appears in: NELFT Stahl online collection

Holdings
Item type	Home library	Collection	Class number	URL	Status	Notes	Barcode
Electronic book	CEME Library (NELFT) Online			Link to resource	Available	NELFT users click here for access, no password required from NELFT computer, OpenAthens login required offsite
Electronic book	Newcomb Library at Homerton Healthcare Online			Link to resource	Available	East London NHS Foundation Trust users only.
Electronic book	South London and Maudsley Trust Library Online	Stahl Online psychopharmacology ebooks	WM 402 (Browse shelf(Opens below))	Link to resource	Available		rhleb050820

Includes bibliographical references and index.

1 Current depression landscape: a state of the field today Laurence Mignon and Stephen M. Stahl
2 Novel therapeutic targets for treating affective disorders Eliyahu Dremencov and Thomas Cremers
3 Developing novel animal models of depression Lotte de Groote and Malgorzata Filip and Andrew C. McCreary
4 Translational research in mood disorders: using imaging technologies in biomarker research Jul Lea Shamy and Adam M. Brickman and Chris D. Griesemer and Anna Parachikova and Mark Day
5 Defining depression endophenotypes Lisa H. Berghorst and Diego A. Pizzagalli
6 Genetic and genomic studies of major depressive disorder Roy H. Perlis
7 Medicinal chemistry challenges in the design of next generation antidepressants David P. Rotella
8 Application of pharmacogenomics and personalized medicine for the care of depression Keh-Ming Lin and Chun-Yu Chen and Yu-Jui Yvonne Wan

The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This is essential reading for all those involved in psychopharmacologic drug development, and mental health clinicians seeking a preview of discoveries soon to influence their practice.

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