Basic clinical radiobiology

Text covers: The significance of radiobiology and radiotherapy for cancer treatment; Irradiation-induced damage and the DNA damage response; Quantifying cell kill and cell survival; Radiation dose-response relationships; Linear energy transfer and relative biological effectiveness; Physics of radiation therapy for the radiobiologist; Tumour growth and response in radiation; Fractionation: the linear-quadratic approach; The linear-quadratic approach in clinical practice; Modified fractionation; Time factors in normal tissue responses to irradiation; The dose-rate effect; Pathogenesis of normal tissue side effects; Stem cells in radiotherapy; Normal tissue tolerance and the effect of dose inhomogeneities; The oxygen effect and the therapeutic approaches to tumour hypoxia; The tumour microenvironment and cellular hypoxia responses; Combined radiotherapy and chemotherapy; Molecular targeted agents for enhancing tumour response; Biological individualisation of radiotherapy; Molecular image guided radiotherapy; Retreatment tolerance of normal tissues; Biological response modification of normal tissue reactions: Basic principles and pitfalls; Hadron therapy: the clinical aspects; Tissue response models; Second cancers after radiotherapy.

This book is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology. Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.