Systemic lupus erythematosus (SLE) : prevalence, pathophysiology, and prognosis [E-Book]

Includes bibliographical references and index.

Description based on print version record.

SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): PREVALENCE, PATHOPHYSIOLOGY AND PROGNOSIS; SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): PREVALENCE, PATHOPHYSIOLOGY AND PROGNOSIS; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: Illustrated Overview of the Prevalence and Clinical Symptoms of Systemic Lupus Erythematosus; Abstract; Introduction; Epidemiology; Constitutional Symptoms; Manifestations of the Involvement of Specific Organs; Gastrointestinal Disease: Digestive System; Renal Disease: Lupus Nephritis; Ophthalmologic Findings; Conclusion; References.

Chapter 2: The Pathophysiology of Systemic Lupus ErythematosusAbstract; Introduction; Genetic Susceptibility; Environmental Triggers; The Source of Autoantigens in SLE; Sex Hormones and SLE; B- and T-Cell Hyperactivity; Autoantibodies in SLE; Cytokines in SLE; Conclusion; References; Chapter 3: MBL and MBL Genotypes in SLE; Abstract; Introduction; References; Chapter 4: Novel Biological Activitiesof Autoantibodies as the Potential Markers of Systemic Lupus Erythematosus; Abstract; Abbreviations; 1. Introduction; 2. Methods; 3. Results and Discussion; Conclusion; References.

Chapter 5: Cytokines in Systemic Lupus Erythematosus (SLE): Clinical Aspects and PrognosticsAbstract; Introduction; Conclusion; References; Chapter 6: Prognosis in Systemic Lupus Erythematosus; Abstract; Systemic Lupus Erythematosus Development and Cardiovascular Involvement; SLE Improved Survival and Therapies; Regular Treatment for SLE; Conclusion; Grants; References; Chapter 7: Autoantibody-Producing RP105-Negative B Cells in Humans and a Murine Model of Lupus Erythematosus; Abstract; Introduction; Conclusion; References; EDITOR CONTACT INFORMATION; Index.

Systemic lupus erythematosus (SLE) is one of the prototypical systemic autoimmune diseases characterized by inflammation, immune complex deposition, and vasculitis. Patients with SLE show various symptoms and clinical images, both constitutional and specific organ symptoms. They include the skin, joints, muscles, kidneys, lungs, nervous system, and blood vessels. Although the etiology of the disease is still unclear, genetic, hormonal, immunologic abnormalities and environmental factors complicatedly play important roles in the pathophysiology in SLE. It is evident that multiple genes show gen.

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