Atopic dermatitis - eczema : clinics, pathophysiology and therapy, [E-Book]

Preface - 1 General Introduction and Epidemiology -- 2 Clinical Symptoms of Atopic Eczema in its different Stages -- 3 Ethnic aspects of atopic dermatitis / eczema -- 4 Do allergies increase in prevalence, and why? -- 5 Environmental influences -- 6 Genetics -- 7 Pathophysiology of Atopic Dermatitis/Eczema -- 8 Management of Patients with Atopic Eczema -- 9 General management -- 10 Treatment of skin barrier dysfunction (emollients) -- 11 The microbiome and therapeutic implications -- 12 Immunomodulatory treatments (topical and systemic) -- 13 Phototherapy -- 14 Psychosomatic influences and psychotherapeutic problems -- 15 Educational programs and the Eczema School -- 16 New treatment options (biologics, kinase inhibitors) -- 17 Preventive aspects -- 18 Concluding Remarks: How to Live with Atopic Eczema.

This entirely revised edition of the successful work presents the state of the art in clinics, research and practical management of atopic dermatitis - eczema. The wide variability in clinical morphology including differences between age groups and ethnicities is illustrated by color pictures including the typical minimal manifestations or "stigmata" suggestive of atopy. The dramatic rise in the prevalence of this disease over the last few decades is reflected by detailed analyses of epidemiological data from all over the world. In-depth descriptions of key pathophysiological mechanisms including epidermal barrier, molecular genetics and modern cellular immunology offer readers a deeper understanding of the complex events leading to the often excruciating symptoms. Treatment - and management - comprises all aspects from elicitor avoidance to basic emollient skin care, immuno-modulating treatments both topical and systemic, up to the latest advances in kinase inhibitors and biologics. In turn, the book discusses the role of the microbiome and antimicrobial treatments as well as phototherapy, provides dietary recommendations for individuals with food allergies, and explores psychosocial aspects of the disease. Environmental influences are considered with regard to irritants and allergens. All recommendations are based on current national and international guidelines. The complex management strategies for this disease have led to the emergence of educational programs (Eczema Schools), which the authors have developed and promoted at the national and international level. This new revised edition of Atopic Dermatitis - Eczema will be an invaluable asset for dermatologists, allergists, pediatricians and general practitioners, but also for all related health personnel and patient organizations interested in gaining a fuller understanding of this widespread skin disease.