Estrogen action, selective estrogen receptor modulators, and women's health : progress and promise [E-Book]

Includes bibliographical references and index.

Print version record.

About the Author and Editor; Contributors; Acknowledgements; Forewords Nancy Brinker Bert W. O'Malley; Introduction: The Foundation of a Career V. Craig Jordan; A NEW STRATEGY: LONG-TERM ADJUVANT TAMOXIFEN; REFERENCES; Chapter 1 A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention V. Craig Jordan; BEGINNINGS AT THE DAWN OF THE 20TH CENTURY; LINKS BETWEEN SEX STEROIDS AND CANCER; CONCEPTUAL PROGRESS THROUGH SCIENTIFIC SERENDIPITY; A TARGET FOR TREATMENT AND PREVENTION; AN UNLIKELY THERAPEUTIC SOLUTION

TARGETING TREATMENT FOR BREAST CANCERCHEMOPREVENTION OF BREAST CANCER; MOLECULAR MECHANISMS OF ESTROGEN AND SERM ACTION; DRUG RESISTANCE TO SERMS; PARALLEL PATH OF THE PROSTATE; THE SUCCESSFUL EVOLUTION OF TARGETED ANTIHORMONAL THERAPY IN THE 20TH CENTURY AND BEYOND; ACKNOWLEDGEMENTS; REFERENCES; Chapter 2 Diethylstilbestrol: A Tragedy in Reproductive Endocrinology But a Pioneering Cancer Treatment Joan Lewis-Wambi and V. Craig Jordan; INTRODUCTION; THE HISTORY OF DES; Side Effects in Women Prescribed DES During Pregnancy (First Generation)

Side Effects in DES Daughters and Sons (Second Generation)Side Effects of DES in the Third Generation; MOLECULAR MECHANISMS OF DES ACTION; MECHANISMS OF DES-INDUCED CARCINOGENESIS; ESTROGEN (DES) THERAPY AND PROSTATE CANCER; ESTROGEN (DES) THERAPY AND BREAST CANCER; MECHANISM OF ESTROGEN-INDUCED APOPTOSIS IN BREAST CANCER; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; Chapter 3 Oral Contraceptives and Women's Health V. Daniel Castracane and V. Craig Jordan; INTRODUCTION AND HISTORY; NONCONTRACEPTIVE BENEFITS; ADVERSE EFFECTS; NEW FORMULATIONS OF THE ESTROGEN-PROGESTIN CONTRACEPTIVES

CONTINUOUS ORAL CONTRACEPTIVESCONTRACEPTION AT MORE THAN 40 YEARS OF AGE; CLOSING THOUGHTS; REFERENCES; Chapter 4 Hormone Replacement Therapy and Women's Health Jennifer Eng-Wong, Ifeyinwa Obiorah and V. Craig Jordan; STRATEGIES IN DISEASE PREVENTION; USAGE OF ESTROGEN REPLACEMENT THERAPY, APPROVALS IN THE UNITED STATES; PREPARATION AND CONTENT OF ERT; RESULTS OF HRT RANDOMIZED TRIALS; HRT and Vascular Disease; HRT and Cancer Risk; Breast Cancer; Gynecologic Cancers; Colon Cancer; Lung Cancer; HRT and Bone Health; HRT and Menopausal Symptoms; HRT and Cognitive Function

HRT and Gallbladder DiseaseSUMMARY; Challenges of the Future; ACKNOWLEDGEMENTS; REFERENCES; Note Added in Proof; Chapter 5 Induction of Ovulation by Nonsteroidal Antiestrogens Ifeyinwa Obiorah and V. Craig Jordan; INTRODUCTION; EARLY TRIALS WITH CLOMIPHENE CITRATE; CLOMIPHENE RESISTANCE; CURRENT CLOMIPHENE THERAPY AND TREATMENT MONITORING; GESTATIONAL OUTCOME WITH CLOMIPHENE AND SIDE EFFECTS; TAMOXIFEN; TAMOXIFEN AND CLOMIPHENE INDUCTION OF OVULATION; THE USE OF TAMOXIFEN IN OVARIAN STIMULATION IN BREAST CANCER PATIENTS; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES

This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs - tamoxifen and raloxifene - are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.

WorldCat record variable field(s) change: 650