Peripheral nerve disorders [E-Book]

Title from online resource (viewed November 12, 2013).

Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities. *Cover both hereditary and cryptogenic neurologic disorders *Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology *Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy.

Includes bibliographical references and index.

Prelude to the peripheral neuropathies -- Microscopic anatomy: normal structure -- Gross anatomy and development of the peripheral nervous system -- Physiology and pathophysiology of myelinated nerve fibers -- Biology of Schwann cells -- Neurophysiological approach to disorders of peripheral nerve -- Testing the autonomic nervous system -- Imaging of the peripheral nervous system -- The nerve biopsy: indications, technical aspects, and contribution -- The cutaneous nerve biopsy: technical aspects, indications, and contribution -- Antibody testing in peripheral nerve disorders -- DNA testing in hereditary neuropathies -- Examination and clinical care of the patient with neuropathy -- How to explore a patient with a chronic axonal polyneuropathy -- Evaluation of a patient with suspected chronic demyelinating polyneuropathy -- Sensory-motor assessment in clinical research trials -- Management of painful neuropathies -- Diagnosis of brachial and lumbosacral plexus lesions -- Compression and entrapment neuropathies -- Facial nerve palsy and hemifacial spasm -- The Guillain-Barre syndrome -- Chronic inflammatory demyelinative polyneuropathy -- Treatment of chronic inflammatory demyelinating polyradiculoneuropathy -- Multifocal motor neuropathy -- Neuropathy and monoclonal gammopathy -- Vasculitic neuropathy -- Sarcoidosis of the peripheral nervous system -- Leprous neuropathy -- HIV peripheral neuropathy -- Human T-cell leukemia virus (HTLV)-associated neuropathy -- Herpes virus infection in the peripheral nervous system -- Lyme neuroborreliosis -- Diabetic neuropathy -- Biology of diabetic neuropathy -- Uremic neuropathy -- Porphyric neuropathy -- Fabry disease -- Transthyretin familial amyloid polyneuropathy -- Hereditary gelsolin amyloidosis -- Malignant cell infiltration in the peripheral nervous system -- Paraneoplastic neuropathy -- Drug-induced neuropathies -- Late radiation injury to peripheral nerves -- Neuromuscular complications of critical illness -- The surgery of peripheral nerves (including tumors) -- Peripheral neuropathy in the elderly -- Dominant Charcot-Marie-Tooth syndrome and cognate disorders -- Recessively transmitted predominantly motor neuropathies -- Early onset (childhood) monogenic neuropathies -- Hereditary sensory and autonomic neuropathies -- Peripheral nerve involvement in hereditary cerebellar and multisystem degenerative disorders -- Giant axonal neuropathy -- Neurofibromatosis type 1 (NF1): diagnosis and management -- Neurofibromatosis type 2 (NF2): diagnosis and management.

Master record variable field(s) change: 072 - OCLC control number change