Clinical pharmacology during pregnancy [E-Book]

1. Introduction References 2. Physiologic Changes During Pregnancy 2.1 Physiologic changes during pregnancy 2.2 Cardiovascular system 2.3 Respiratory system 2.4 Renal system 2.5 Gastrointestinal system 2.6 Hematologic and coagulation systems 2.7 Endocrine system 2.8 Summary References 3. Impact of Pregnancy on Maternal Pharmacokinetics of Medications 3.1 Introduction 3.2 Effects of pregnancy on pharmacokinetic parameters 3.3 Summary References 4. Medications and the Breastfeeding Mother 4.1 Medication use by the breastfeeding mother 4.2 Clinical pharmacology of drug transfer into breast milk 4.3 During delivery 4.4 General anesthesia 4.5 Epidural anesthesia 4.6 Galactogogues 4.7 Immediate postpartum period 4.8 Pain 4.9 Methadone 4.10 Resumption of pre-pregnancy medications 4.11 Psycho- and neurotropic drugs 4.12 Drugs not to give to the nursing mother postpartum 4.13 Oral contraceptives (OCPs) 4.14 Summary 4.15 Where to find information References 5. Fetal Drug Therapy 5.1 Introduction 5.2 Indications for fetal therapy 5.3 Strategies to achieve fetal drug therapy 5.4 Special considerations Acknowledgments References 6. Treating the Placenta: an Evolving Therapeutic Concept 6.1 Introduction 6.2 The placenta as the therapeutic target: the past 6.3 The placenta: therapeutic targets 6.4 The placenta as a therapeutic target today 6.5 The placenta as a therapeutic target in the future Conclusion"

Includes bibliographical references and index.

Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations.