Acute lung injury : epidemiology, health effects and therapeutic treatment strategies [E-Book]

Includes bibliographical references and index.

Print version record.

ACUTE LUNG INJURY: EPIDEMIOLOGY, HEALTH EFFECTS AND THERAPEUTIC TREATMENT STRATEGIES; ACUTE LUNG INJURY: EPIDEMIOLOGY, HEALTH EFFECTS AND THERAPEUTIC TREATMENT STRATEGIES; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: TRALI Not a Two Hit, But a Multi-Causal Model; Center for Clinical Transfusion Research, Sanquin Research, Leiden; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Abstract; Introduction; Threshold Models; A More General Threshold Model of Multi-Causality; The Sufficient Cause Model; Discussion.

ConclusionReferences; Chapter 2: Mechanisms and Prevention of Pulmonary Microvascular Hyperpermeability in Acute Lung Injury; Abstract; Introduction; Pulmonary Microvascular Hyperpermeability; in Acute Lung Injury; The Mechanisms of Pulmonary Microvascular Hyperpermeability in Acute Lung Injury; Macrophages; Neutrophils; Platelets; Cell Organelles; Small G Protein; Calcium; HMGB1; Cell Junctions; Nitric Oxide (NO) and Inducible Nitric Oxide Synthase (iNOS); Focal Adhesions (FAs) Complex and FA Kinase (FAK); Hyperoxia; Prospective Approach to Heal ALI; References.

Chapter 3: Pharmacological Therapies for Acute Respiratory Distress SyndromeAbstract; Introduction; Corticosteroids; Neutrophil Elastase Inhibitors; Anticoagulant Therapies; Conclusion; References; Chapter 4: Novel Trends in Pharmacotherapy of Acute Lung Injury and Acute Respiratory Distress Syndrome; ABSTRACT; Definition of ALI/ARDS; Pathophysiology of ALI/ARDS as a Rationale for the Treatment; Pharmacotherapy of ALI/ARDS; Types, Dosage and Delivery of Exogenous Surfactants; Effects of Surfactant Administration; Complications of Surfactant Administration.

Surfactant Treatment in the Neonates and ChildrenSurfactant Treatment in the Adult Patients; Inhaled Nitric Oxide (iNO); Aerosolized Prostacyclin; Non-conventional Approaches (Cell and/or Gene Therapy); Cell-Based Approaches; Gene-Based Therapy; Cell-Delivered Gene Therapy; Conclusion; References; Editor Contact Information; Index.

In this book, authors review the current knowledge on acute lung injury (ALI). ALI/acute respiratory distress syndrome (ARDS) is characterized by diffuse alveolar damage, alveolar capillary leakage, lung edema, neutrophil-derived inflammation, and surfactant dysfunction. These changes lead to clinical manifestations of decreased lung compliance, severe hypoxemia, and bilateral pulmonary infiltrates. In the first chapter the authors describe how two different models of multi-causality (intuitively appealing threshold model and abstract sufficient cause model), both of which are commonly used in.

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