Environmental Endocrinology and Endocrine Disruptors : Endocrine and Endocrine-targeted Actions and Related Human Diseases / [E-Book]

Environmental endocrinology: basic concepts -- Environmental impact on the hypothalamus-pituitary axis -- Environmental impact on the hypothalamus-pituitary-thyroid axis -- Environmental impact on the hypothalamus-pituitary-adrenal axis -- Environmental impact on the hypothalamus-pituitary-ovary axis -- Environmental impact on female fertility and pregnancy -- The role of the environment in female reproductive disorders -- Environmental impact on the hypothalamus-pituitary-testis axis -- Environmental impact on semen quality and male fertility -- The role of the environment in testicular dysgenesis syndrome -- Environmental impact on sexual response -- Environmental impact on bone health -- Environmental impact on the immune system -- Environmental impact on metabolism -- The role of the environment in neuroendocrine tumors -- The role of the environment in endocrine cancers -- The role of the environmentin hormone-related cancers.

This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to 'living editions' that are constantly updated using a dynamic peer-review publishing process.