000			03992nam a22004815i 4500
001			978-981-19-7122-8
003			DE-He213
005			20240729133705.0
007			cr nn 008mamaa
008			221208s2022 si | s |||| 0|eng d
020			_a9789811971228 _9978-981-19-7122-8
024	7		_a10.1007/978-981-19-7122-8 _2doi
072		7	_aMFG _2bicssc
072		7	_aMED075000 _2bisacsh
072		7	_aMFG _2thema
100	1		_aGao, Yuansheng. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aBiology of Vascular Smooth Muscle _b : Vasoconstriction and Dilatation /
250			_a2nd ed. 2022.
264		1	_aSingapore : _bSpringer Nature Singapore : _bImprint: Springer, _c2022.
300			_aXV, 424 p. 1 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aArchitecture of the vessel wall -- Ultrastructure of vascular smooth muscle -- Vascular endothelium -- Electrical and mechanical properties of vascular smooth muscle -- Biochemistry of the contractile proteins of smooth muscle -- Metabolism of vascular smooth muscle -- Neurotransmitters -- Endothelium-derived factors -- Local metabolic factors -- Shear stress, myogenic response, and blood flow autoregulation -- Intracellular Ca2+ regulation -- Regulation of myosin light chain phosphorylation -- Cyclic AMP signaling -- Cyclic GMP signaling -- MicroRNAs and vasoreactivity -- Extracellular vesicles as unique signaling messengers -- Genetic and epigenetic modification -- Coronary vasoreactivity -- Cerebral vasoreactivity -- Pulmonary vasoreactivity -- Renal vasoreactivity -- Hypoxic vasoreactivity -- Ageing and vasoreactivity.
520			_aThis book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.
650		0	_aHuman physiology.
650		0	_aPhysiology. _97429
650		0	_aInternal medicine. _96654
650		0	_aMedicine _xResearch.
650		0	_aBiology _xResearch.
650	1	4	_aHuman Physiology.
650	2	4	_aPhysiology. _97429
650	2	4	_aInternal Medicine. _96654
650	2	4	_aBiomedical Research.
710	2		_aSpringerLink (Online service)
856			_u#gotoholdings _yAccess resource
912			_aZDB-2-SBL
912			_aZDB-2-SXB
245			_h[E-Book]
999			_c100684 _d100684