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001 978-981-16-6092-4
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008 220211s2022 si | s |||| 0|eng d
020 _a9789811660924
_9978-981-16-6092-4
024 7 _a10.1007/978-981-16-6092-4
_2doi
072 7 _aMMGT
_2bicssc
072 7 _aMED106000
_2bisacsh
072 7 _aMKGT
_2thema
100 1 _aChidambaram, Saravana Babu.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aIntroduction to Toxicological Screening Methods and Good Laboratory Practice
250 _a1st ed. 2022.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2022.
300 _aXX, 189 p. 1 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aChapter 1. Introduction to Toxicology -- Chapter 2. Laboratory Animal models -- Chapter 3. Toxicology Screening Methods -- Chapter 4. Toxicokinetics -- Chapter 5. Safety Pharmacology -- Chapter 6. Good Laboratory Practice.
520 _aThis book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule 'Y', India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
650 0 _aToxicology.
_98159
650 0 _aPharmacology.
_97400
650 0 _aMedical sciences.
650 0 _aDrug development.
650 0 _aPharmacy.
650 0 _aPharmaceutical chemistry.
650 1 4 _aToxicology.
_98159
650 2 4 _aPharmacology.
_97400
650 2 4 _aPreclinical Research.
650 2 4 _aPharmacy.
650 2 4 _aPharmaceutics.
700 1 _aEssa, M. Mohamed.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
700 1 _aQoronfleh, M. Walid.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
710 2 _aSpringerLink (Online service)
856 _u#gotoholdings
_yAccess resource
912 _aZDB-2-SBL
912 _aZDB-2-SXB
245 _h[E-Book]
999 _c101033
_d101033