000 03877nam a22005295i 4500
001 978-3-031-06566-8
003 DE-He213
005 20240729134155.0
007 cr nn 008mamaa
008 221015s2022 sz | s |||| 0|eng d
020 _a9783031065668
_9978-3-031-06566-8
024 7 _a10.1007/978-3-031-06566-8
_2doi
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
072 7 _aMJCM
_2thema
245 1 0 _aPI3K and AKT Isoforms in Immunity
_b : Mechanisms and Therapeutic Opportunities /
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2022.
300 _aVII, 466 p. 42 illus., 37 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x2196-9965 ;
_v436
505 0 _aClass I PI3K biology -- Class II PI3K biology -- Class III PI3K biology -- PTEN in immunity -- PHLPP Signaling in Immune Cells -- PHLPP Signaling in Immune Cells -- PI3K isoforms in cell signalling and innate immune cell responses -- AKT isoforms in macrophage activation, polarization and survival -- Control of CD4+ T cell Differentiation and Function by PI3K isoforms. -- PI3K isoforms in CD8+ T cell development and function -- PI3K isoforms in B cells -- PI3K isoform signalling in platelets -- PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection -- PI3K and AKT at the Interface of Signaling and Metabolism -- The Role of PI3K Isoforms in Autoimmune Disease -- AKT Isoforms in the Immune Response in Cancer -- PI3K isoform immunotherapy for solid tumours -- PI3K targeting in non-solid cancer -- AKT isoforms as a target in cancer and immunotherapy -- Developing PI3K Inhibitors for Respiratory Diseases.
520 _aThis book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body's own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
650 0 _aImmunology.
650 0 _aImmune system.
_96566
650 0 _aCellular signal transduction.
650 0 _aCytology.
650 0 _aAutoimmunity.
650 0 _aImmunospecificity.
650 1 4 _aImmunology.
650 2 4 _aImmune Cell Signalling.
650 2 4 _aCell Biology.
650 2 4 _aAutoimmunity.
650 2 4 _aAdaptive Immunity.
700 1 _aDominguez-Villar, Margarita.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
830 0 _aCurrent Topics in Microbiology and Immunology,
_x2196-9965 ;
_v436
856 _u#gotoholdings
_yAccess resource
912 _aZDB-2-SBL
912 _aZDB-2-SXB
245 _h[E-Book]
999 _c101188
_d101188