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020 _a9783030959753
_9978-3-030-95975-3
024 7 _a10.1007/978-3-030-95975-3
_2doi
072 7 _aMMB
_2bicssc
072 7 _aMED006000
_2bisacsh
072 7 _aMKA
_2thema
245 1 0 _aBlood Substitutes and Oxygen Biotherapeutics
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2022.
300 _aXX, 448 p. 103 illus., 83 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aATP and Oxygen: the Energy Economy of the Cell -- Physiological Functions of Blood -- Hemoglobin: Physiology and Hemoglobinopathy -- The Global Burden of Anemia -- Blood Component Therapy: the History, Efficacy, and Adverse Effects in Clinical Practice -- Allogeneic Blood Transfusion: Complications and Side Effects -- The real-time effects of artificial blood substitutes on the microcirculation -- Vascular endothelium and nitric oxide -- A Brief History of Development of Nanobiotechnology-based Blood Substitutes -- Classification of Blood Substitutes -- Hemoglobin-based Oxygen Carriers -- Complications of HBOCs including clinical safety issues -- Free Hemoglobin Toxicity -- Nanotechnology-based oxygen and drug carriers -- Perfluorocarbon-based Oxygen Carriers -- Platelet Substitutes -- Plasma Substitutes -- Novel nanobiotherapeutic based blood substitutes -- Paradigm Shift -- Hemoglobin-Based Blood Substitute -- Hemoglobin vesicles as artificial red cells -- Low Volume Resuscitation Agents in Prehospital Medicine -- ErythroMer: Bio-Inspired Artificial Red Blood Cell -- OxyVita-Erythrocruorin -- HemAssist: History, clinical trials -- Development of Recombinant Hemoglobin -- Hemolink-PolyHeme -- Safety and Tolerability Study -in Stable Adult Patients with Sickle Cell disease -- Oxygent-Sanguinate -- M101, the Hemoglobin from the Sea-Hemopure: clinical trials and current status -- Perftoran: History-Oxycyte-Hemoximer -- Transplantation -- Hemorrhagic Shock: HBOCs in Trauma -- Use of Oxygen -- Regulatory Update.
520 _aThis book functions as a comprehensive and authoritative reference book in blood transfusion and blood substitutes. It is a collection of the latest developments and the newest investigations, and individual chapters are written by world experts in the arena. The book begins with a historical review on the practice of transfusions as well as the components and physiology of blood. The following chapters cover various topics, including platelet substitutes, hemoglobin-based oxygen carriers, perfluorocarbon based oxygen carriers, and safety issues related to artificial hemoglobin. All chapters provide a bulleted highlights list to facilitate readers in mastering the main points of each individual chapter. Blood Substitutes and Oxygen Biotherapeutics is an invaluable reference book for perioperative care providers, hematologists, anesthesiologists, surgeons, obstetricians and gynecologists.
650 0 _aAnesthesiology.
650 0 _aHematology.
650 0 _aSurgery.
650 1 4 _aAnesthesiology.
650 2 4 _aHematology.
650 2 4 _aSurgery.
700 1 _aLiu, Henry.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aKaye, Alan D.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aJahr, Jonathan S.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
856 _u#gotoholdings
_yAccess resource
912 _aZDB-2-SME
912 _aZDB-2-SXM
245 _h[E-Book]
999 _c101621
_d101621