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001 978-3-030-84744-9
003 DE-He213
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007 cr nn 008mamaa
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020 _a9783030847449
_9978-3-030-84744-9
024 7 _a10.1007/978-3-030-84744-9
_2doi
072 7 _aMNS
_2bicssc
072 7 _aMED065000
_2bisacsh
072 7 _aMNS
_2thema
245 1 0 _aOrthobiologics
_b : Injectable Therapies for the Musculoskeletal System /
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2022.
300 _aXI, 402 p. 73 illus., 66 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aI. Injectable OrthoBiologics: Formulations and Rationale 1. Bone marrow-derived cultured stromal cells and Bone Marrow Concentrate -- 2. Adipose-derived cultured stromal cells and Stromal Vascular Fraction from adipose tissue -- 3. Synovial-derived cultured stromal cells -- 4. Amniotic, Placenta, and Umbilical cord-derived cultured stromal cells -- 5. Allogeneic cells: pros and cons -- 6. Steroid hormones -- 7. Cytokines, chemokines, alpha-2-macroglobulin, growth factors -- 8. Platelet-rich plasma: leucocyte-rich, leukocyte-poor, autologous conditioned serum, autologous protein solution -- 9. Amniotic tissue extract, placenta tissue extract -- 10. Extracellular vesicles (exosomes) -- II. Injectable OrthoBiolologics: evaluation methods and results based on pathology and anatomy -- 11. Rotator cuff tendinopathy: cell therapy -- 12. Rotator cuff tendinopathy: biologics -- 13. Tennis elbow: cell therapy -- 14. Tennis elbow: cell therapy biologics -- 15. Patellar tendinopathy: cell therapy -- 16. Patellar tendinopathy: biologics -- 17. Achilles tendinopathy: cell therapy -- 18. Achilles tendinopathy: biologics -- 19. Plantar Fasciitis: cell therapy -- 20. Plantar Fasciitis: biologics -- 21. Ligament lesions: cell therapy -- 22. Ligament lesions: biologics -- 23. Meniscal lesions: cell therapy -- 24. Meniscal lesions: biologics -- 25. Muscle lesions: cell therapy -- 26. Muscle lesions: biologics -- 27. Fractures (incl. Nonunions): cell therapy -- 28. Fractures (incl. Nonunions): biologics -- 29. Cartilage lesions and Osteoarthritis of the knee: cell therapy -- 30. Cartilage lesions and Osteoarthritis of the knee: biologics -- 31. Cartilage lesions and Osteoarthritis of the hip and ankle: cell therapy -- 32. Cartilage lesions and Osteoarthritis of the hip and ankle: biologics -- III. Future directions 33. Pluripotent stem cells: Embryonic/Fetal stem cells and induced pluripotent stem (iPS) cells -- 34. Gene therapy -- 35.Stimulation of the intrinsic stromal cell niche -- 36 Conclusions.
520 _aThis book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies - ranging from tendinopathies through non-unions to articular degenerative processes - as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.
650 0 _aOrthopedics.
650 0 _aSports medicine.
650 0 _aRegenerative medicine.
650 0 _aMedical sciences.
650 1 4 _aOrthopaedics.
650 2 4 _aSports Medicine.
650 2 4 _aRegenerative Medicine and Tissue Engineering.
650 2 4 _aHealth Sciences.
700 1 _aFilardo, Giuseppe.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMandelbaum, Bert R.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMuschler, George F.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRodeo, Scott A.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aNakamura, Norimasa.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
856 _u#gotoholdings
_yAccess resource
912 _aZDB-2-SME
912 _aZDB-2-SXM
245 _h[E-Book]
999 _c101749
_d101749