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001 978-3-031-24575-6
003 DE-He213
005 20240729135210.0
007 cr nn 008mamaa
008 230303s2023 sz | s |||| 0|eng d
020 _a9783031245756
_9978-3-031-24575-6
024 7 _a10.1007/978-3-031-24575-6
_2doi
072 7 _aMJD
_2bicssc
072 7 _aMED010000
_2bisacsh
072 7 _aMJD
_2thema
245 1 0 _aLipoprotein(a)
250 _a1st ed. 2023.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Humana,
_c2023.
300 _aXVII, 443 p. 92 illus., 76 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aContemporary Cardiology,
_x2196-8977
505 0 _a60 years of Lp(a) research-From Ouchterlonys double diffusion to a significant risk factor for CHD -- Lp(a) structure and composition -- Genetics of Lipoprotein(a) -- Lp(a) metabolism -- Contemporary aspects of Lp(a) metabolism and therapies based on tracer kinetic methods -- Role of Proprotein Convertase Subtilisin Kexin type 9 in Lipoprotein(a) Metabolism -- The Role of Cell Surface Receptors in Lp(a) Metabolism -- Physiological Roles And Functions Of Lipoprotein(a) -- The role of Lp(a) in Atherosclerosis: An overview -- Role of macrophages in Lp(a) pathophysiology -- Thrombosis, Inflammation and Lipoprotein(a): Clinical Implications -- The role of the kidney in Lp(a) physiology and pathophysiology -- Lp(a) as a cardiovascular risk factor -- Lp(a) and aortic valve stenosis, stroke, and other non-coronary cardiovascular diseases -- Lp(a) in cardiovascular disease: Evidence from Large Epidemiological Studies -- Lipoprotein(A) And Immunity -- When to measure Lp(a) -- Measurement of Lipoprotein (a) in the Clinical Laboratory -- Standardization of analytical methods for the measurement of Lipoprotein(a): bridging past and future initiatives -- Establishing an SI-traceable Reference Measurement System for Lp(a), based on Quantitative Protein Mass Spectrometry and Molar Units -- Compounds that impact Lp(a) concentrations -- Antisense oligonucleotide therapy to treat elevated lipoprotein(a) -- Lipoprotein apheresis for reduction of Lipoprotein(a) -- Elevated Lp(a) - Why Should I Test For It, If I Cannot Treat It? A Patient's Perspective -- Burning unanswered questions Therapy.
520 _aLipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease. Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still very low among health care providers. Even cardiologists often overlook Lp(a), in part because Lp(a) is not as well-understood as other risk factors and treatment options are still very limited. This book offers an authoritative and comprehensive overview of Lipoprotein(a). It provides an in-depth review of all aspects of Lp(a), from pathophysiology to metabolism. Chapters offer the reader a contemporary view of the important roles of Lp(a) as a risk factor for cardiovascular disease. In addition, this volume discusses the clinical implications of elevated Lp(a) and current and future therapies. Lipoprotein(a) is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.
650 0 _aCardiology.
650 0 _aInternal medicine.
_96654
650 1 4 _aCardiology.
650 2 4 _aInternal Medicine.
_96654
700 1 _aKostner, Karam.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aKostner, Gerhard M.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aToth, Peter P.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
830 0 _aContemporary Cardiology,
_x2196-8977
856 _u#gotoholdings
_yAccess resource
912 _aZDB-2-SME
912 _aZDB-2-SXM
245 _h[E-Book]
999 _c102495
_d102495