000 04337nam a22004575i 4500
001 978-3-031-16286-2
003 DE-He213
005 20240729135914.0
007 cr nn 008mamaa
008 230228s2023 sz | s |||| 0|eng d
020 _a9783031162862
_9978-3-031-16286-2
024 7 _a10.1007/978-3-031-16286-2
_2doi
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
072 7 _aMJCL
_2thema
100 1 _aSchulz, Wolfgang A.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aMolecular Biology of Human Cancers
250 _a2nd ed. 2023.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2023.
300 _aXXI, 542 p. 229 illus., 221 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
520 _aThis textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
650 0 _aCancer.
650 0 _aMedicine
_xResearch.
650 0 _aBiology
_xResearch.
650 0 _aOncology.
_913364
650 1 4 _aCancer Biology.
650 2 4 _aBiomedical Research.
650 2 4 _aOncology.
_913364
710 2 _aSpringerLink (Online service)
856 _u#gotoholdings
_yAccess resource
912 _aZDB-2-SBL
912 _aZDB-2-SXB
245 _h[E-Book]
999 _c103378
_d103378