000 03442nam a22004575i 4500
001 978-981-99-4318-0
003 DE-He213
005 20240821195035.0
007 cr nn 008mamaa
008 230919s2023 si | s |||| 0|eng d
020 _a9789819943180
_9978-981-99-4318-0
024 7 _a10.1007/978-981-99-4318-0
_2doi
072 7 _aPSAK
_2bicssc
072 7 _aSCI029000
_2bisacsh
072 7 _aPSAK
_2thema
100 1 _aChhaya, Pradeep.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 4 _aThe Topological Model of Genome and Evolution
_b : Understanding the Origin and Nature of Life /
250 _a1st ed. 2023.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2023.
300 _aXXIII, 546 p. 1 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aChapter 1_Nature of Life: Structuralism and functionalities -- Chapter 2_Nature of Relationship Between: A Genotype and A Phenotype -- Chapter 3_Nature of Genomic Architecture: A Topological Model of Genome -- Chapter 4_Biological Algorithm of Involution: Ontology of Gene Expressions -- Chapter 5_Nature of Developmental Processes in Mammals -- Chapter 6_Nature of Aging Process: Genomic Ontology of Aging -- Chapter 7_Nature of Genomic Evolution: Its imprint in Cancer -- Chapter 8_Nature of Regulatory Genome: The Evolution and Natural Selection of Genotope -- Chapter 9_Principles of Genomic Evolution.
520 _aThis book deals with the missing link in the domain of functional genomics viz. genomic architecture. It begins with a deconstruction of the Darwinian paradigm using the proposed model of modified involuted manifolds. It recasts the process of natural selection as a process of information transfer. Using a topological model, this book outlines a new genomic architecture. The key argument for this proposed model is that some such structuralism has always been implicit in genomics. The proposed model fits very well with the known genomic characteristics and allows to separate the regulatory genome from the transcriptive genomes. The model is capable of discerning modular architecture of genomes with different genomic functionalities existing in hierarchical relationships and demonstrates that genomes act as units of selection and as the environment for the individual genes which act as competing species. Towards the end, the book also examines the role of genomic evolution in cancer and the principles of natural selection and evolution of the genotype. The regulatory genome is also discussed, with an emphasis on its evolution and natural selection. It is a valuable source for researchers working in functional genomics, mathematical modeling in biology and evolutionary genomics. .
650 0 _aGenetics.
650 0 _aEvolution (Biology).
650 0 _aEvolutionary genetics.
650 1 4 _aGenetics and Genomics.
650 2 4 _aEvolutionary Biology.
650 2 4 _aEvolutionary Theory.
650 2 4 _aEvolutionary Genetics.
710 2 _aSpringerLink (Online service)
856 _u#gotoholdings
_yAccess resource
912 _aZDB-2-SBL
912 _aZDB-2-SXB
245 _h[E-Book]
999 _c103700
_d103700