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001 978-3-031-36390-0
003 DE-He213
005 20240729140319.0
007 cr nn 008mamaa
008 231103s2023 sz | s |||| 0|eng d
020 _a9783031363900
_9978-3-031-36390-0
024 7 _a10.1007/978-3-031-36390-0
_2doi
072 7 _aPSD
_2bicssc
072 7 _aPSBC
_2bicssc
072 7 _aSCI008000
_2bisacsh
072 7 _aPSD
_2thema
245 1 0 _aRNA Structure and Function
250 _a1st ed. 2023.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2023.
300 _aXI, 666 p. 134 illus., 123 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aRNA Technologies,
_x2197-9758 ;
_v14
505 0 _a1. Computational Tools for Functional Analysis of Circular RNAs -- 2. The Hidden Layer of RNA Variants -- 3. Functional Role of Non-Coding RNAs in Prostate Cancer: From Biomarker to Therapeutic Targets -- 4. The structure, function, and modification of non-coding RNAs in cardiovascular system,- 5. Contribution of RNA Species in Sexually Transmitted Infections -- 6. Hypoxia and Epithelial-to-Mesenchymal Transition (EMT) in Cancer: A Non-Coding RNA Perspective -- 6. A Study on the Role of piRNAs in Cancer Epigenetics -- 7. Modified Nucleosides as RNA Components. Structure, Biological Role and Drug Design -- 8. Multifaceted Functions of RNA m6A Modification in Modulating Regulated Cell Death -- 9. Incorporation of Pseudouridine into RNA for Biochemical and Biophysical Studies -- 10. Molecular Dynamics Simulations of Chemically Modified Ribonucleotides.
520 _aThis book focuses on the current status of our understanding of RNA, a key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA, noncoding RNAs, modified nucleosides, and RNA enzymes. The different chapters detail methods to investigate RNA structure and function, the chemistry of modified RNAs, and the latest advances in our understanding of the vast array of biological processes in which RNA is involved. RNA, in one form or another, touches almost everything in a cell. RNA has both structural and catalytic properties. RNA fulfills a broad range of functions. These molecules are no longer seen as passive elements transferring the genetic information from DNA into proteins but regulate the activity of genes during development, cellular differentiation, and changing environments. RNAs are involved in various aspects of cell physiology and disease development. Discoveries of RNA with unexpected diverse functions in healthy and diseased cells,such as the role of RNA as both the source and countermeasure to cancer or severe viral infection, stimulate new trends, passion, and solutions for molecular medicine. In this book, fundamental questions about the biochemical and genetic importance of RNA, how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, how to determine RNA structure and how to apply RNA in treatment of diseases. This book is an essential resource for researches in academia and industry contributing to the development of new RNA therapeutics. The book is geared toward scientists from the graduate level on up and particularly appeals to active investigators in RNA biology, molecular biology, and biochemistry.
650 0 _aBiomolecules.
650 0 _aPhysical biochemistry.
650 0 _aMacromolecules.
650 0 _aBiochemistry.
650 0 _aMedical genetics.
650 0 _aCytology.
650 0 _aGenetics.
650 1 4 _aStructural Biology.
650 2 4 _aBiochemistry.
650 2 4 _aMedical Genetics.
650 2 4 _aCell Biology.
650 2 4 _aGenetics and Genomics.
700 1 _aBarciszewski, Jan.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
830 0 _aRNA Technologies,
_x2197-9758 ;
_v14
856 _u#gotoholdings
_yAccess resource
912 _aZDB-2-SBL
912 _aZDB-2-SXB
245 _h[E-Book]
999 _c103804
_d103804