000			04730cam a2200589 i 4500
001			ocn923009432
003			OCoLC
005			20240729131931.0
006			m d
007			cr |||||||||||
008			150425s2015 nyu ob 001 0 eng
010			_a 2020688007
040			_aDLC _beng _erda _cDLC _dN$T _dYDXCP _dEBLCP _dD6H _dAU@ _dSTF _dSCB
019			_a947129237
020			_a9781634829175 _qebook
020			_a1634829174
020			_z9781634829052 _qhbk.
020			_z1634829050 _qhbk.
035			_a1078033 _b(N$T)
035			_a(OCoLC)923009432 _z(OCoLC)947129237
072		7	_aHEA _x039000 _2bisacsh
072		7	_aMED _x014000 _2bisacsh
072		7	_aMED _x022000 _2bisacsh
072		7	_aMED _x112000 _2bisacsh
072		7	_aMED _x045000 _2bisacsh
049			_aMAIN
245	0	0	_aMyotonic dystrophies : _bepidemiology, diagnosis and therapeutic challenges _c _h[E-Book]
264		1	_aNew York : _bNova Biomedical, _c[2015]
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aNeuroscience research progress
504			_aIncludes bibliographical references and index.
588			_aDescription based on print version record.
505	0		_aMYOTONIC DYSTROPHIES EPIDEMIOLOGY, DIAGNOSIS AND THERAPEUTIC CHALLENGES ; MYOTONIC DYSTROPHIES EPIDEMIOLOGY, DIAGNOSIS AND THERAPEUTIC CHALLENGES ; Contents ; Preface ; Chapter 1 Epidemiology of Myotonic Dystrophy in the Molecular Era: Implications for Clinical Trials and Association Studies ; Abstract ; Introduction ; The Population Origins of DM1 ; The Epidemiology of DM1 ; The Epidemiology of DM2 ; Implications for Clinical Trials and Association Studies ; Conclusion ; References ; Chapter 2 Detecting and Targeting RNA: Biomarkers and Therapy for Myotonic Dystrophy ; Abstract
505	8		_aIntroduction Development of Biomarkers for Myotonic Dystrophy Type 1 (DM1) ; Blood-based Biomarkers ; Tissue Biomarkers ; Cerebrospinal Fluid Biomarkers ; Potential Therapeutic Applications for DM1 ; Targeting the Pathogenic DM1 RNA Transcripts ; Exogenous Induction of MBNL1 and CUGBP1 Protein Activity ; Conclusion; References; Chapter 3 Endocrine System Involvement in Myotonic Dystrophy: Emerging Interactions and Potential Therapeutic Strategies ; Abstract; Introduction ; Parathyroid and Thyroid-Related Hormones ; Vitamin D ; Insulin Resistance and Metabolic Syndrome
505	8		_aAdrenocortical Activity Hypogonadism and Fertility ; Conclusion ; References ; Chapter 4 Central Nervous System Involvement in Myotonic Dystrophies ; Abstract ; Introduction ; Cognitive Impairment in Myotonic Dystrophy Type 1 (DM1, Steinert's Disease) ; Cognitive Involvement in DM2 ; Sleep Related Disorders in DM1 and DM2 ; Conclusion ; References ; Chapter 5 Strategies for Neuromuscular Blockade in Patients with Myotonic Dystrophy ; Abstract ; The Physiology of Neuromuscular Transmission ; Myotonic Pathophysiology from an Anaesthesiology Viewpoint ; Premedication
505	8		_aInduction of Anaesthesia Response to Muscle Relaxants ; Reverse of Neuromuscular Blockade ; Other Perioperative Triggers ; Management of Anaesthesia in Patients with Myotonic Dystrophy; Caesarean Section ; Scoliosis Surgery ; General Surgery ; Conclusion ; Acknowledgment ; Reference; Chapter 6 Functional Assessment and Rehabilitative Treatment in Myotonic Dystrophy Type 1 ; Abstract ; Introduction; 1. Functional Assessment ; 1.1. Muscle Strength; 1.2. Posture and Gait Abilities ; Clinical Evaluation: Muscle Efficiency ; Rehabilitative Treatment ; References
505	8		_aChapter 7 Protein Kinase Inhibitors As Potential Therapeutic Agents to Ameliorate Pathogenesis of Myotonic Dystrophy Type 1 (DM1) Abstract ; Introduction; Toxicity of Mutant CUG Repeat RNA and Misregulation of Proteins in DM1 ; Therapeutic Approaches in DM1 ; Potential Mechanisms of Action of Small Molecule Kinase Inhibitors ; Conclusion ; Acknowledgments ; References ; Chapter 8 Variant Interrupted DMPK Alleles: Implications in the Pathogenesis and Molecular Diagnosis of Myotonic Dystrophy Type 1 (DM1) ; Abstract; Molecular Genetics of the DM1 Mutation
590			_aMaster record variable field(s) change: 050, 082
650		0	_aMyotonia atrophica _xTreatment.
650		2	_aMyotonic Dystrophy _xtherapy.
700	1		_aJenkins, Sandra _c(Writer on Myotonic dystrophies), _eeditor.
830		0	_aNeuroscience research progress.
856			_u#gotoholdings _yAccess resource
938			_aProQuest Ebook Central _bEBLB _nEBL4189164
938			_aYBP Library Services _bYANK _n12428456
938			_aEBSCOhost _bEBSC _n1078033
942			_n0
994			_a92 _bN$T
999			_c92279 _d92279