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049 _aMAIN
100 1 _aLaplane, Lucie,
_d1984-
_eauthor.
245 1 0 _aCancer stem cells :
_bphilosophy and therapies
_c
_h[E-Book]
264 1 _aCambridge, Massachusetts :
_bHarvard University Press,
_c2016.
300 _a1 online resource (x, 252 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aPart I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer?
520 _a"An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."--Provided by publisher.
588 0 _aPrint version record.
590 _aMaster record variable field(s) change: 072
650 0 _aCancer cells.
650 0 _aStem cells.
650 0 _aCancer
_xTreatment
_xPhilosophy.
650 0 _aOncology.
_913364
650 1 2 _aNeoplastic Stem Cells.
650 2 2 _aStem Cells.
650 2 2 _aNeoplasms
_xtherapy.
856 _u#gotoholdings
_yAccess resource
938 _aEBSCOhost
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938 _aYBP Library Services
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