000			02430nam a22002897a 4500
008			240201b2023 |||||||| |||| 00| 0 eng d
020			_a9781009258081 _q(hardback)
020			_z9781108582285 _q(epub)
040			_aDNLM/DLC
041	0		_aeng
042			_apcc
060	0	0	_aWL 385
245	0	2	_aA complex systems approach to epilepsy : _bconcept, practice and therapy / _cedited by Rodney C. Scott, J. Matthew Mahoney.
260			_aCambridge ; _bCambridge University Press, _c2023.
263			_a2208
300			_avii, 160p : _bill. ; _c26cm.
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction -- Systems biology approaches to the genetic complexity of epilepsy -- Transcriptomic and epigenomic approaches for epilepsy -- Phenomenological mesoscopic models for seizure activity -- Personalized network modeling in epilepsy -- The baseline and epileptiform EEG : a complex systems approach -- Neuronal approaches to epilepsy -- Mapping epileptic networks with scalp and invasive EEG : applications to epileptogenic zone localization and seizure prediction -- A neuroimaging network-level approach to drug-resistant epilepsy -- Epilepsy as a complex network disorder: insights from functional MRI.
520			_aThe epilepsies are devastating neurological disorders for which progress developing effective new therapies has slowed over recent decades, primarily due to the complexity of the brain at all scales. This reality has shifted the focus of experimental and clinical practice toward complex systems approaches to overcoming current barriers. Organized by scale from genes to whole brain, the chapters of this book survey the theoretical underpinnings and use of network and dynamical systems approaches to interpreting and modeling experimental and clinical data in epilepsy. The emphasis throughout is on the value of the non-trivial, and often counterintuitive, properties of complex systems, and how to leverage these properties to elaborate mechanisms of epilepsy and develop new therapies. In this essential book, readers will learn key concepts of complex systems theory applied across multiple scales and how each of these scales connects to epilepsy.
650	1	2	_aEpilepsy
650	1	2	_aSystems Analysis
650	2	2	_aSystems Biology
700	1		_aScott, Rod, _eeditor.
700	1		_aMahoney, J. Matthew, _eeditor.
942			_n0
999			_c98399 _d98399